Transforming Growth factor beta (TGF-beta) in Skin Serums

Transforming growth factor beta, most commonly known as TGF-beta or TGF-β, is an important growth factor found in antiaging serums. TGF-beta in skin increases collagen production, so it is found in many antiaging serums. However, growth factors in skin care products can be unstable and may not penetrate into the skin. (1) So- are TGF-β serums worth the money? Maybe and maybe not.

There are so many antiaging skin serums with antiaging ingredients. How do you know which is best?

The only scientific way to find the best growth factor or antiaging serum for you is to shop by your Baumann Skin Type.

What is TGF-β?

TGF-beta is the most important growth factor that regulates production of the extracellular matrix (ECM) proteins such as collagen, and elastin and the glycosaminoglycan sugars in the skin such as hyaluronic acid and heparan sulfate.

There are a few types of TGF-beta.

TGF-β1 is the type found in skin care products ad used as a treatment for skin rejuvenation, antiaging, and wound healing.(2)

TGF-beta in Skin

Transforming Growth Factor Beta (TGF-beta) is a multifunctional cytokine belonging to the transforming growth factor superfamily. These proteins play critical roles in the regulation of various cellular processes, including cell proliferation, differentiation, migration, and apoptosis. In mammals, the TGF-beta family is composed of several isoforms, such as TGF-beta1, TGF-beta2, and TGF-beta3, all of which are synthesized as precursor proteins and later become activated through a complex maturation process. TGF-beta acts as a potent regulator of many aspects of immune function, wound healing, and tissue regeneration, and it plays a key role in the development and homeostasis of several tissues.

What natural TGF-beta does in skin

In the context of skin health, TGF-beta plays a vital role in maintaining skin integrity and healing. It promotes the synthesis of extracellular matrix components, including collagen, elastin, and fibronectin, which are crucial for skin strength and elasticity. During wound healing, TGF-beta is essential in the regulation of inflammation and the recruitment of cells to the injury site, where it aids in tissue repair and scar formation. Additionally, it helps to regulate the balance of cell proliferation and differentiation in the skin, ensuring that the skin maintains its normal structure and function.

Dysregulation of TGF-beta signaling has been implicated in various skin conditions, including scarring, fibrosis, and certain inflammatory disorders.

How TGF-beta Increases Skin Collagen

Transforming growth factor beta (TGF-β) is a superstar when it comes to collagen production in the skin. This powerful protein regulates cell growth, proliferation, and differentiation, making it a key player in wound healing and skin rejuvenation.

When TGF-beta binds to receptors on fibroblast cells in the dermis, it kicks off a signaling cascade that ultimately ramps up collagen synthesis. Studies show that TGF-beta stimulates fibroblasts to produce more collagen types I and III, the predominant structural collagens that make up over 90% of the dermal matrix.

TGF-beta also inhibits collagen breakdown by blocking matrix metalloproteinases.

In addition, TGF-beta attracts immune cells called macrophages to wound sites, where they secrete more TGF-β to further drive collagen accumulation. This cytokine can even induce fibroblasts to transform into activated myofibroblasts, which synthesize abundant collagen during skin repair.

TGF-β Skin Benefits

TGF-β has many skin benefits because it turns on processes in the skin that make it stronger and younger. It affects many processes that play a role in skin aging. For this reason, good TGF-b products can improve fine lines and skin texture.

This antiaging growth factor:

stimulates dermal collagen remodeling increases the production of collagen,(1)

increases production of hyaluronic acid (4)

decreases matrix metalloproteinases (5) that break down these important skin components.

How does TGF-beta Work?

When the TGF-β receptor is activated, the TGF-β/Smad pathway is turned on. This important pathway helps rejuvenate skin.

Do TGF-beta serums really work

TGF-beta is applied topically to skin as a serum, cream, or lotion that is designed to be absorbed into the skin. The TGF-b molecule itself is relatively large, making its penetration through the outermost layer of the skin (the stratum corneum) somewhat challenging. To enhance its penetration, it is often encapsulated in liposomes or other delivery systems that allow it to reach the deeper layers of the skin where it can exert its effects.

The efficacy of topical TGF-beta skin products can vary, depending on the formulation and the individual’s skin type. Research on the effectiveness of topically applied TGF-beta is ongoing, but some studies suggest that it can have beneficial effects on skin appearance, including reducing the appearance of wrinkles and improving skin texture and tone, presumably by stimulating collagen production and other skin-renewing processes. However, not all formulations may be effective.

Skin care products with TGF-beta

The brand with the best TGF-B in skin care is Plated SkinScience. Their revolutionary use of cutting-edge anti-aging technology makes them one of the best brands on the market today! These are my favorite Plated SkinScience Products:

What is the link between TGF-β and skin aging?

UV radiation inhibits the TGF-β/Smad pathway. in a process called extrinsic aging. Blocking the TGF-β/Smad pathways contributes to photoaging, wrinkled skin, and the development of skin cancer.(6)

How can you increase levels of Transforming growth factor beta in skin

Besides applying TGF-b in skin serums, there are other ways to coerce fibroblasts to secrete more TGF-β.

17β-estradiol increases TGF-β production (7)

Topically applied retinoids increase TGF-β/Smad pathway activity.(8)

Fibroblasts that are in hypoxic conditions produce more TGF-β.(9)

This is another reason I love retinoids to treat wrinkled skin.

Is TGF-β safe to use on skin?

TGF-β seems safe to use on skin; in fact, a decrease in TGF-β may predispose skin to cancer, but much more data is needed.(10,11)

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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