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Glycerin (Glycerol) in Skin Care
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Glycerin (Glycerol) in Skin Care

10 February 2025


Glycerin (Glycerol) in Skin Care




Glycerin (Glycerol) in skin care



Glycerin (glycerol) is one of the most popular moisturizing ingredients in skin care products.




It is a potent humectant with decades of research supporting its effectiveness in hydrating skin.



Studies have found that normal hydration of the skin requires the presence of glycerol. (5) It is one of the most important parts of healthy, hydrated skin.




If you have a dry skin concern, glycerin (glycerol) might be the perfect addition to your custom skin care regimen.



What is Glycerin in skin care?




Glycerin in skin care is a simple sugar alcohol present in most biologic life. The words glycerin and glycerol are interchangeable in skin care; they’re the same thing.



Fats in the body are made partially of triglycerides, which are multiple glycerol molecules attached to one another. Therefore, glycerin can be synthesized from many kinds of animal fats. (3)




Plant fats also contain triglycerides, and some glycerin is sourced exclusively from plants. This means that some glycerin products are vegan and some are not.



Skin care companies are not required to label their glycerin as vegan or animal based. If you are looking for vegan glycerin products, some brands do write “vegetable glycerin” on their labels.




Keep in mind that if the label says “glycerin” or “glycerol,” without mentioning vegetables, it could be animal based glycerin.



Glycerin structure




How does Glycerin work?



Glycerin is a unique moisturizer with several properties that make it a good moisturizing ingredient.




Glycerin’s Humectant Properties



Glycerin is a humectant, meaning it draws water into itself. Humectants are one of the most common types of moisturizing ingredients in skin care. (9)




Studies have found that glycerin has particularly strong humectant properties among the competition, and assists in hydrating enzymes needed to break down the connective proteins between cells. (3)



Glycerin Passes through Aquaporin Channels




Glycerin has the fairly unique ability to navigate AQP-3 (aquaporin) channels. Aquaporin channels are structures that pass between individual skin cells; this means that glycerin can move between skin cells and get deep into the skin better than many other ingredients. Water is one of the only other common ingredients capable of using these AQP-3 pathways. (6)



Glycerin has been used for years in cosmetics for its known humectant properties, and the recent discovery that it can use AQP-3 channels means it is likely to be used for years to come. (8)




What are the benefits of glycerin in skin care



What are the benefits of Glycerin in skin care?




Like most humectants, the primary benefit of glycerin in skin care is as a moisturizing ingredient.



Studies have demonstrated the crucial role glycerol plays in skin hydration; the hydration of your stratum corneum (SC) (the outermost layer of skin) is directly related to your skin’s glycerol levels. (2)




In one study comparing 16 moisturizing ingredient’s efficacy across 394 subjects with dry skin, glycerin products were found to have by far the most profound hydrating effects. (3)



In addition, glycerin products were found to keep the skin hydrated for longer after application than other products, including the standard for preventing water loss, petrolatum. (3)




Because of glycerin’s ability to navigate aquaporin channels, it is able to move between skin cells and create spaces for other ingredients to move between those cells. (4)


Side-effects

Humectants like glycerin are generally free from significant side effects, however there are a few considerations to make before you add a humectant to your skin care routine.

First, if you live in a dry climate and have dry skin, you should pair your glycerin products with occlusive moisturizers that prevent TEWL. Humectants bring moisture to the surface of your skin, and if the air is dry you will lose that moisture without an occlusive.

Second, if you are experiencing any kind of puffiness on your eyelids, humectants can actually worsen that puffiness.

Finally, lip balms without occlusive ingredients can result in TEWL as well; this can leave you feeling dependent on your lip balm for moisture. This has been called “lip balm addiction.”

Keep these features of glycerin and other humectants in mind while you look for the perfect products for your skin type.

is glycerin safe?

Is it safe?

Glycerin has been studied extensively for safety concerns, and is considered safe.

The Cosmetic Ingredient Review board (CIR) released a report on various glycerides and has provided their stamp of approval. (11)

Glycerin is rated 1-2 by the EWG.

Glycerin may be considered a clean ingredient if it is plant derived.

If need a humectant,moisturizing ingredient for your skin care routine, glycerin could very well be the right choice for you!

For specific skin conditions

Glycerin is one of the best, most common, and cheapest moisturizing ingredients on the market; it’s great for skin conditions that benefit from a potent humectant and increased SC fluidity. (5,6)

In general, dry skin conditions like eczema, ichthyosis, psoriasis, and pruritis can all be treated with glycerin products. We recommend pairing glycerin with an occlusive ingredient such as an oil when using glycerin to treat eczema or psoriasis.

Besides dry skin conditions, glycerol is also useful for delivering other ingredients further into the skin. For this reason, you can often find glycerin in anti-aging and inflammation products. (4,10)

If you have a specific skin concern, be sure to take the best skin type quiz so you can shop for treatments by your Baumann Skin Type.

The best solution to any skin concern is having the right custom skin care regimen.

Eczema

Eczematic skin is, (to oversimplify), skin that has a hard time holding water, for that reason, ingredients that hydrate the skin are good for eczema.

If you are going to use a humectant like glycerin on eczema, be sure to include an occlusive ingredient so you don’t lose all the accumulated moisture into the atmosphere.

The best eczema treatments include a combination of different kinds of ingredients with complimentary anti-inflammatory, barrier repairing, and hydrating properties.

If you have eczema, consider some of these cleansers to use in your routine!

For Wrinkles

While glycerin does not itself remedy aging skin or wrinkles, it can be useful for helping anti-aging ingredients interact with the skin.

Studies have found that using glycerin alongside ingredients which struggle to penetrate skin (glycolic acid was studied) makes a significant impact in absorption. (10)

Anti-aging ingredients typically are antioxidants, collagen or elastin stimulating, or exfoliating; glycerin is none of those things.

Glycerin does not perform any of those functions, so it is really just used as a hydrating delivery system for other ingredients in wrinkle treatments.

However, its immense ability to bind water helps temporarily puff up the skin and make fine lines look instantly better. The results are temporary.

This ability to plump up the skin makes glycerin a favorite ingredient to get “glass skin”.

glycerin vs hyaluronic acid

Glycerin vs Hyaluronic acid

Glycerin and hyaluronic acid are functionally similar ingredients, but they are have very different structures. There are a few notable differences between these two ingredients even though they’re both humectants.

Of these two compounds, only glycerin is able to move through the AQP-3 (aquaporin) channels in the skin, meaning it is better at hydrating deep in the skin. (4)

Glycerin is a sugar-based alcohol, while hyaluronic acid is a glycosaminoglycan – a disaccharide (a different, more complex kind of sugar)

Glycerin is cheaper to synthesize than hyaluronic acid, meaning glycerin products tend to be more affordable.

As the word “acid” indicates, hyaluronic acid has a low pH, meaning it might be a better choice for low pH cleansers than glycerol.

Glycerin vs Polyglutamic acid

Polyglutamic acid is a chemical usually derived from food fermentation. It is related to the “umami” flavor compound glutamic acid. (MSG stands for mono-sodium glutamate.)

Because it is formed through fermentation, polyglutamic acid is harder and more expensive to synthesize than glycerin.

It is actually a far more potent humectant than glycerin and expresses anti-aging properties. (12) but it cannot use the aquaporin channels in the skin the way glycerin can.

Glycerin vs honey

Honey is a fascinating ingredient in skin care that varies in properties based on the flowers and bees it came from. In general, however, honey always contains glycerin. (13-15)

The glycerin in honey provides its notable moisturizing, humectant qualities.

Honey is a complexly composed ingredient, full of various phenols, flavonoids, fatty acids, and vitamins; it is acidic too.

Glycerin is a singular compound that serves a unique function as a humectant that can pass through AQP-3; honey is a broader ingredient that happens to contain glycerin.

Products

As one of the most popular moisturizing ingredients in all of skin care, there are no shortage of options for skin care products made with glycerin. It is found in varying amounts in the vast majority of products for dry skin. You can find our collection of products for dry skin here!

Before you choose your favorite, be sure to take our quiz and find your Baumann Skin Type. The best way to be sure the products you buy will work for you is to shop by your skin type!

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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