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Dioscorea villosa in Topical Skincare: Hormonal Implications and Dermatologic Uses
Skin Care

Dioscorea villosa in Topical Skincare: Hormonal Implications and Dermatologic Uses

24 May 2025


The Science of Wild Yam in Skin Care

Many influencers who focus on natural and herbal ingredients have identified wild yam as an effective anti-aging skin care ingredient.

Although there is little scientific research on the effectiveness of wild yam as an anti-aging skin care product.

There is evidence that its anti-inflammatory and so-called estrogenic effects may help make skin look and feel younger, especially for women in menopause.

However, due to these estrogenic properties, wild yam cream may not be right for every woman.

Before diving into wild yam and its potential effects on your skin, you should know your skin type so you can better assess whether this ingredient is worth trying.

In skin care, wild yam root may relieve wrinkles and dryness caused by estrogen deficiency.

There is limited scientific evidence that wild yam has cosmetic benefits in skin care.

Women with a history of breast or ovarian cancer should consult their doctor before using wild yam cream.

Eating wild yam may increase estradiol and estrogen levels, but applying wild yam topically is unlikely to have such an effect.

What is wild yam (Dioscorea villosa)?

Wild yam, scientifically known as Dioscorea villosa, is a perennial vine native to North America.

It has been used traditionally in herbal medicine for centuries, particularly by Native American tribes.

The plant is characterized by its heart-shaped leaves and tuberous roots, which contain a variety of bioactive compounds.

The roots of the plant are often harvested and processed into extracts, creams, and capsules for use not only in skin care, but also as a natural remedy for menopausal symptoms.

Again, little research has been done on its potential to effectively relieve menopausal symptoms, although at least one study suggests that short-term use of wild yam may have no side effects (3).

Estrogenic Effects

Wild yam generally has the ability to affect hormone levels, especially estrogen. During menopause, estrogen levels in the body drop significantly, leading to dry skin and increased wrinkling.

Estrogen plays a key role in the production of collagen, an important protein that keeps skin firm and youthful.

Wild yam contains so-called phytoestrogens, which can mimic the functions of estrogen in the body. For this reason, it is often used in skin care products for women during menopause.

However, there is little data to support this hypothesis.

Wild yam does not contain any true estrogen. It does contain phytoestrogens that can bind to estrogen receptors.

This could mean that applying wild yam root topically in a skin care product could help relieve symptoms such as dry skin and wrinkles that are associated with low estrogen levels.

However, research (3) suggests that topical creams containing wild yam root do not relieve menopausal symptoms.

However, consuming wild yams can affect hormone levels, such as estrogen levels (5).

Active Ingredients in Wild Yams

Wild yam root contains several active ingredients that can also have positive effects on the skin when applied topically:

Dioscin. Dioscin is a steroidal saponin that is a precursor to several hormones, including progesterone.

In skin care, dioscin is thought to promote skin health through its anti-inflammatory and antioxidant effects.

Saponins. Saponins in wild yam are thought to exert their anti-inflammatory properties by modulating the inflammatory process, thereby soothing irritated or inflamed skin.

Saponins can also help other active ingredients penetrate the skin.

Flavonoids. Wild yams contain a variety of flavonoids, a class of polyphenols with powerful antioxidant properties.

Flavonoids protect the skin from oxidative stress by neutralizing free radicals, thereby reducing or preventing the damage they can cause to skin cells.

Starch and fiber. While they don’t work directly like saponins or flavonoids, the starch and fiber in wild yams can form a protective barrier to retain moisture and improve skin hydration.

When added to topical formulations, they can improve skin smoothness and elasticity.

Benefits of Wild Yams in Skin Care

The many active ingredients in wild yam root can provide a variety of benefits to the skin, including:

Anti-aging effects. The estrogenic effects of wild yam root can help reduce signs of aging such as dryness, wrinkles, or thinning of the skin caused by decreased estrogen levels in women.

In addition, the antioxidant properties of wild yam root can help reduce signs of skin aging caused by free radicals.

Improved hydration. The starch and fiber in wild yams can form a protective barrier on the surface of the skin to help retain moisture.

Additionally, the saponins found in wild yam roots can boost the absorption of other moisturizing ingredients, which can improve the skin’s overall hydration and elasticity.

Calming Effects. Wild yams can soothe irritated or inflamed skin due to their anti-inflammatory properties, making them suitable for sensitive skin.

Side Effects of Wild Yams in Skin Care

Wild yam creams may have some important side effects that you should be aware of, including:

Hormone Imbalances. Wild yams contain diosgenin, a compound that can mimic estrogen in the body. Overuse can disrupt natural hormone balance.

Therefore, consult your doctor before use, especially if you already have a hormonal imbalance.

Allergic Reactions. Some people may experience skin irritation, redness, or allergic reactions when using wild yam creams.

Digestive Problems. While it’s rare for wild yams to be used topically, they may cause nausea, vomiting, or indigestion if consumed.

Wild Yams and Cancer Risk: What Are the Studies Saying?

There is still controversy over whether wild yams affect cancer risk, especially the risk of hormone-dependent cancers such as breast and ovarian cancer.

Concerns arise from the potential estrogenic effects of wild yam, as elevated estrogen levels have been linked to an increased risk of these cancers.

However, scientific research on wild yam and its direct effects on cancer risk is limited and inconclusive.

Most studies focus on diosgenin, a compound in wild yam that mimics estrogen, although it does not necessarily have the same function in the body.

Current evidence does not clearly support the hypothesis that wild yam creams significantly increase cancer risk, but it cannot be ruled out, especially for women with a history of breast or ovarian cancer.

Due to the lack of solid evidence, people with a history of breast cancer, ovarian cancer, or other hormone-related conditions should consult a doctor before using wild yam products.

Who should avoid using wild yam root?

While topical use of wild yam in skin care may not be enough to produce systemic hormonal effects, people with the following characteristics and conditions should avoid wild yam in their diet and skin care:

Women with a history of estrogen-dependent cancers such as breast and uterine cancer

Boys and men

Pregnant women

Melasma or hyperpigmentation

Products containing wild yam

There are many creams containing wild yam. The leading brand is Neocutis, which uses wild yam extract in a variety of anti-aging moisturizers.

Conclusion: Does Wild Yam Really Have Skin Care Benefits?

The effectiveness of wild yam for skin care depends largely on your individual skin type and specific needs.

Although many people report positive results from using wild yam products, scientific evidence regarding estrogenic effects and overall benefits is still lacking.

The active ingredients in wild yam may have benefits, especially in treating dryness, irritation, and signs of aging.

However, people with specific health conditions or hormonal imbalances should consult a doctor before starting to take wild yam.

Men should avoid using and consuming products and foods that contain large amounts of wild yam.

DQH Knowledge drop: In your 20s, your skin cell turnover decreases. (Cell turnover is a key component in keeping your skin youthful.) You know what else slows down? Your collagen production. Starting in your 20s, collagen decreases by about 1 percent per year. Should you want to prevent fine lines and wrinkles, start by eliminating behaviors that contribute to premature aging. “If it’s bad for you, it’s bad for your skin,” says dermatologist Michel Somenek. “Cigarette smoking reduces blood flow to the skin and causes premature wrinkling and a dull skin texture. Making the repeated pursed motion to inhale can also cause smoker’s lines. Alcohol and recreational drugs are toxins for the skin that damage its cellular structure and DNA,” Somenek tells us. “The faster you eliminate vices while you are young, the better chance your skin and body have to recuperate.” Also, adopting an anti-aging routine in your 20s is key. After all, the best offense is a good defense. We spoke to Somenek and experts Joshua Ross and Audrey Kunin to find out more. Keep reading for the best anti-aging products for your 20s, according to skincare professionals. Sunscreen “We all know that the sun is the number one cause of skin aging and starting the prevention in your 20s is very important,” Ross says. “The majority of your sun damage won’t start to appear until you’re in your 30s, so don’t wait until you see it surface or you’ll be behind the curve. Stay ahead of it with a good-quality zinc-based sunscreen worn daily.” Farmacy Green Defense Daily Mineral Sunscreen An invisible sunscreen with SPF 30, plus botanical extracts meant to protect skin with tons of antioxidants. Bonus: It’s clean and fine to use under makeup. Bareminerals Complexion Rescue™ Tinted Moisturizer Broad Spectrum SPF 30 Although we recommend you use your SPF and moisturizer separately, we also understand moments when you don’t have time or energy for that extra step. For those times, this bareMinerals moisturizer is a great thing to have on hand. Vitamin C Serum “A great introduction to anti-aging is to start with a vitamin C serum in your morning skincare routine,” Ross says. “It’s a powerful antioxidant that will neutralize free radicals and brighten the skin.” He adds that it’s a great way to counteract the effects of the sun’s harmful rays, which, as previously mentioned, are among the biggest causes of premature aging. Drunk Elephant C-Firma™ Vitamin C Day Serum The Drunk Elephant C-Firma is a lightweight serum that promises to give skin a glow by combining the brightening powers of vitamin C with ferulic acid, l-ascorbic acid, and vitamin E. The included sodium hyaluronate is meant to replace hydration loss, so you shouldn’t have to deal with any irritation. Sunday Riley C.E.O. Rapid Flash Brightening Serum This potent serum is jam-packed with vitamin C (15 percent, to be exact), which means it’s a potential superstar at both brightening skin and dousing it in antioxidants. Peptides Using peptides on your skin has many benefits, says Somenek. “The skin barrier is what defends the body against pollution, UV rays, bacteria, and toxins. It can be damaged by several everyday factors. Using topical peptides aids in building a stronger barrier,” he says. “Peptides comprise elastic fibers, which are a type of protein. These fibers help to make skin appear taut and firm. Peptides can also help repair damaged skin, relieve inflammation, and even out skin tone. Some peptides can kill acne-causing bacteria that is common in 20-somethings.” Kunin agrees, saying, “Peptides are an excellent entry point for supporting collagen.” She recommends looking for face and eye treatments that contain these collagen-boosting powerhouses. Charlotte Tilbury Magic Eye Rescue Cream This Charlotte Tilbury super-emollient eye cream has a base of coconut oil and shea butter (read: it’s incredibly hydrating). Botanicals plus peptides are meant to help reduce dark circles and boost collagen, respectively. This creamy moisturizer serves up potent collagen-boosting peptides and pycnogenol, and antioxidant-rich vitamin C. “Instead of sitting on top of the skin, peptides penetrate the outer layer so they go deep. The ‘signals’ they send tell the cells to produce elastin and collagen, which are needed for youthful-looking skin,” explains Somenek. At-Home Peel Pads Remember that skin cell turnover fiasco we talked about earlier? One way to help support it is by exfoliating. “Exfoliation is important to help keep skin fresh and luminous,” Kunin says. She recommends using at-home peel pads as an easy and effective way to exfoliate. “The goal in your 20s is to fight the slowing pace of cell turnover. It is wise to use products that gently exfoliate, yet still remove oil and other impurities. Products that have Alpha Hydroxy Acids (AHA) or Beta Hydroxy Acids (BHA) are a good choice.” According to Somenek, you should only exfoliate two to three times a week. “People of all ages are guilty of over-exfoliating and that can be too much of a good thing,” he says. Dermadoctor Kakadu C Intensive Vitamin C Peel Pad A few swipes of this Derma Doctor powerful peel pad promise to leave your skin glowing and smooth, thanks to the seven (yes, seven) types of chemical exfoliants, including AHA and BHA. It also contains vitamin C via Kakadu plum extract for added brightening and antioxidant protection. KEY INGREDIENTS Kakadu plum extract is sourced from the Kakadu plum, a fruit grown in northern Australia. It contains vitamin C, which restores the skin’s natural barrier, increases collagen production, and soothes irritation. Dr. Dennis Gross Skincare Alpha Beta® Universal Daily Peel Pads These are the gold standard of peel pads, with a cult following and over 900 five-star reviews on Sephora. They’re easy to use and contain a blend of anti-aging exfoliating acids. Emollient Night Cream “In your 20s, you need to start upping the hydration in your skincare routine. You may have been cautious of over-moisturizing because of acne in your teens, but as you enter your 20s, your skin transitions and becomes drier,” Ross says. “I recommend an emollient night cream added into your evening skincare regimen.” “Twenty-somethings need to make sure that they are not using creams that will clog their pores and cause excess oil production,” says Somenek. Opt for non-comedogenic products. Cerave Skin Renewing Night Cream One great choice is the CeraVe Skin Renewing Night Cream, which is a non-comedogenic night cream that leaves skin soft and glowy. It combines the moisturizing powers of ceramides and hyaluronic acid. RoC Retinol Correxion Max Hydration Creme “The best night cream ingredients contain retinol, benzoyl peroxide, and/or salicylic acid or hyaluronic acid. The goal is to moisturize, yet remove excess oil,” says Somenek. This Roc Retinol Correxion cream fits the bill as it contains both hyaluronic acid and retinol so it promises to moisturize while also being non-comedogenic.
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