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Squalene vs. Squalane: What They Are and Their Skincare Benefits
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Squalene vs. Squalane: What They Are and Their Skincare Benefits

6 June 2025



What Is Squalene And What Are Its Skincare Benefits?

If you check the ingredients list of many skincare products, you will likely come across both squalene and squalane.

Though their names sound almost identical, that small difference in spelling actually signals a big difference in their properties and uses.

It’s easy to get confused, but once you understand these two molecules better, the picture becomes much clearer.

So, let’s dive in and explore what squalene really is and why it’s such a valuable ingredient in skincare.

What’s the Difference Between Squalene and Squalane?

Squalene is a natural lipid that is found in our bodies, primarily in the skin. It plays an important role in keeping skin looking youthful, soft, supple, and well-hydrated.

However, like many of the beneficial substances our bodies produce, the levels of squalene start to decrease as we age.

This decline often coincides with dry skin, fine lines, wrinkles, and other signs of skin aging.

The problem with using squalene directly in skincare products is that it is chemically unstable.

It easily oxidizes when exposed to air, which makes it unsuitable for inclusion in most cosmetic formulations.

To solve this issue, squalene undergoes a chemical process called hydrogenation, transforming it into squalane.

Squalane is a more stable and shelf-friendly version of squalene, which can be safely added to skincare products.

A helpful analogy is to think of squalene and squalane as twins. Squalene is the wild one who might party all night, while squalane is the responsible twin who goes to bed early.

Both have their benefits, but squalane is the one you’ll find in most skincare products because it is stable and effective.

Where Does Squalene Come From?

Historically, squalene was sourced from shark liver oil because sharks produce very high amounts of it.

However, this practice raised serious ethical and environmental concerns due to the impact on shark populations and ocean ecosystems.

Fortunately, modern skincare companies now mainly derive squalene from plant-based sources.

Common natural sources include olives, rice bran, and sugarcane, making the ingredient much more sustainable and cruelty-free.

This shift to plant-based squalene has made squalane an even more popular and desirable skincare ingredient.

You can feel good about using products that contain it, knowing they support both your skin and the environment.

Fast Facts About Squalene

Naturally produced by the human body, especially in the skin

Helps maintain skin hydration but decreases after age 30

Traditionally extracted from shark livers but now mostly plant-derived

Unstable in raw form, so it is hydrogenated to form squalane

Squalane is the stable, safe, and effective version found in skincare

Works as a powerful emollient and antioxidant for skin health

What Does Squalene Do for Your Skin?

Squalene is a powerful hydrating booster that enhances your skin’s moisture levels and promotes a radiant, healthy complexion.

Its antioxidant properties help combat free radicals—unstable molecules that cause damage to skin cells and accelerate aging.

By neutralizing these free radicals, squalene protects your skin’s texture, appearance, and overall functionality.

One of the key benefits of squalane-based skincare is its ability to help repair damage caused by sun exposure and environmental aggressors.

It can reduce the appearance of early signs of aging such as fine lines, wrinkles, and loss of firmness by supporting collagen production and maintaining skin elasticity.

Using squalane regularly can help keep your skin looking plump, smooth, and youthful while strengthening its natural barrier.

This protective barrier locks in moisture and shields the skin from irritants and pollutants.

Which Skin Types Can Benefit from Squalene?

One of the best things about squalene and squalane is that they are suitable for almost all skin types.

Dry skin benefits from its deep hydration and nourishing properties, making it an excellent substitute for heavier facial oils.

People with oily or acne-prone skin appreciate that squalane is non-comedogenic, which means it won’t clog pores or trigger breakouts.

Even those with sensitive or reactive skin, including conditions like rosacea and eczema, can benefit from squalane’s anti-inflammatory properties.

It helps soothe irritation and redness while reinforcing the skin’s protective barrier. Since squalane is typically odorless and gentle, it is unlikely to cause irritation.

However, as with any new skincare product, it’s wise to introduce it gradually and watch for any reactions.

How Do You Use Squalene or Squalane in Your Skincare Routine?

Squalane is found in a variety of skincare products, including cleansers, serums, facial oils, and moisturizers.

Because it is gentle and well-tolerated, many people can use multiple squalane-containing products throughout their daily routine.

If you’re concerned about overloading your skin, start with a serum or moisturizer that contains squalane.

These products tend to stay on the skin longer and deliver lasting hydration while helping to restore the skin’s youthful glow.

Applying squalane after cleansing and before heavier creams allows it to lock moisture into your skin effectively.

Squalane pairs well with other hydrating ingredients like hyaluronic acid and ceramides, creating a comprehensive moisture defense system.

Is Squalene Better Than Hyaluronic Acid?

Both squalene (or squalane) and hyaluronic acid are beloved skincare ingredients known for their hydration benefits, but they work differently.

Hyaluronic acid is a humectant, meaning it draws water from the environment and deeper skin layers into the surface, helping skin retain moisture.

However, its ability to hold moisture isn’t long-lasting on its own.

Squalane, on the other hand, works by locking moisture into the skin and strengthening the skin’s barrier.

This allows it to hold hydration for longer periods, helping maintain softness and suppleness throughout the day.

When used together, these ingredients complement each other for optimal skin hydration and protection.

For a deep dive into hyaluronic acid benefits, you can check out skincare blogs dedicated to that ingredient, but rest assured squalane is a fantastic addition to any routine.

Are There Any Risks or Dangers to Using Squalene?

Generally, squalane and squalene are very safe ingredients with low risk of irritation or allergic reactions.

Nonetheless, it’s always advisable to perform a patch test when introducing any new product into your routine, especially if you have sensitive skin.

Apply a small amount of the product to a discreet area and wait 24 hours to see if any redness, itching, or swelling occurs. If no adverse reaction appears, it’s safe to use.

The biggest concern when it comes to squalene is not a risk to your skin but the source of the ingredient.

Always check that the squalene or squalane you purchase is plant-derived rather than extracted from shark liver oil, as the latter raises ethical and environmental issues.

Final Thoughts

Squalene and squalane are remarkable skincare ingredients that provide deep hydration, antioxidant protection, and anti-aging benefits.

Thanks to advancements in sourcing and formulation, you can now enjoy all the perks of this natural molecule in a sustainable and cruelty-free way.

With its versatility and suitability for nearly every skin type, squalane is a wonderful addition to your skincare routine.

It helps keep skin younger-looking, healthier, and beautifully hydrated. While the names may be confusing at first, the results will make it all worthwhile.

So next time you see squalane or squalene on a label, you’ll know exactly what they mean — and how great they are for your skin!

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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