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The Ultimate Guide: What to Avoid Mixing with Vitamin C
Skin Care

The Ultimate Guide: What to Avoid Mixing with Vitamin C

8 June 2025


What Should You Not Mix Vitamin C With?

Vitamin C is one of the most celebrated ingredients in skincare. Its potent antioxidant properties help to rejuvenate the skin, reduce dark spots, and combat free radical damage.

However, there are some common questions around which ingredients you should avoid mixing with vitamin C.

Many people are unsure about how to incorporate vitamin C into their skincare routine without causing irritation or negative reactions.

So, in this article, we’ll explore which products you should avoid combining with vitamin C and which ingredients work best alongside it.

What Can You Not Mix with Vitamin C?

While vitamin C has incredible benefits, it is considered slightly unstable, especially when mixed with other potent ingredients.

It has a more acidic pH level, which means it can be challenging to combine with certain active ingredients. Here are the main ingredients you should avoid mixing with vitamin C:

Vitamin C and Retinol

Retinol is another powerhouse ingredient known for its anti-aging properties. It boosts collagen production, speeds up skin cell turnover, and promotes a firmer, youthful complexion.

However, using vitamin C and retinol together is not recommended. Both are highly effective ingredients, but they work best on their own.

The problem lies in the pH levels. Vitamin C is acidic, while retinol works best in a neutral to slightly alkaline environment.

When used together, they can neutralize each other, reducing their effectiveness. Additionally, using both can cause excessive irritation, redness, and peeling, especially for sensitive skin.

To make the most of both ingredients, you can use them at different times of the day.

Apply vitamin C in the morning, followed by a broad-spectrum SPF (minimum SPF 30), as vitamin C can make the skin more sensitive to the sun.

Use retinol at night as its potency is most effective during the evening and will not be compromised by sunlight.

Vitamin C and Niacinamide

Niacinamide, or Vitamin B3, is a versatile ingredient used in many skincare products for its ability to hydrate, regulate sebum production, and improve skin texture.

However, mixing niacinamide with vitamin C is a controversial topic in the skincare community.

Many believe these two ingredients don’t work well together because they can counteract each other’s effects.

Niacinamide is known for being a soothing and anti-inflammatory ingredient, whereas vitamin C is a potent brightening agent. When used together, niacinamide can reduce the effectiveness of vitamin C.

This means that applying them in the same routine might not deliver the full benefits of either ingredient.

The pH levels of vitamin C and niacinamide also differ, which could cause irritation and decreased performance.

If you want to include both in your routine, it’s best to apply them at different times of the day.

Vitamin C works best in the morning, while niacinamide can be used in the evening. Alternatively, you can also layer them with a 10-15 minute interval between each to avoid any issues.

Vitamin C and AHAs/BHAs

Alpha Hydroxy Acids (AHAs) and Beta Hydroxy Acids (BHAs), like glycolic acid and salicylic acid, are popular for their exfoliating properties.

 

These acids help to slough off dead skin cells and improve skin texture. However, combining AHAs/BHAs with vitamin C can be too harsh for the skin.

Both AHAs/BHAs and vitamin C have low pH levels. When applied together, they can cause irritation, excessive dryness, redness, and peeling.

Moreover, the acidic nature of these two ingredients can disrupt your skin’s natural pH balance, potentially leading to weakened skin barriers.

To prevent irritation, it’s advisable to avoid using AHAs/BHAs and vitamin C together in the same routine.

If you want to incorporate both, consider alternating them on different days or times of the day. For example, use AHAs/BHAs in the evening and vitamin C in the morning.

What Can Vitamin C Be Mixed With?

While vitamin C should not be mixed with certain ingredients, there are several other skincare actives that complement its benefits and work effectively alongside it.

When combined with the right ingredients, vitamin C can provide even more impressive results. Here are some ingredients that mix well with vitamin C:

1. Vitamin E

Vitamin E is a powerful antioxidant that helps protect the skin from environmental damage. When combined with vitamin C, the two ingredients work synergistically to enhance each other’s effectiveness.

Vitamin E helps stabilize vitamin C, making it more stable and potent. This combination not only provides antioxidant protection but also supports the skin’s natural moisture barrier.

The duo of vitamin C and vitamin E helps to brighten the skin, reduce pigmentation, and promote a more youthful complexion.

If you’re looking for a potent antioxidant serum, this combination is a great choice.

2. Ferulic Acid

Ferulic acid is another antioxidant that works wonders when paired with vitamin C. It helps stabilize and protect the vitamin C in your skincare routine, making it more effective.

Ferulic acid also has its own skin-protecting properties, helping to reduce the appearance of fine lines and wrinkles, as well as preventing UV-induced damage.

When combined with vitamin C and vitamin E, ferulic acid provides superior antioxidant protection against free radicals.

This trio works effectively together to brighten the skin, reduce oxidative stress, and protect the skin from environmental damage.

3. Vitamin B (Vitamin B5, B3)

Vitamin B3, also known as niacinamide, can work well with vitamin C when applied at separate times of the day, as discussed earlier.

However, other B vitamins, such as vitamin B5, work wonderfully with vitamin C. Vitamin B5 has hydrating properties that help to soothe and moisturize the skin.

When paired with vitamin C, vitamin B5 can enhance the skin’s ability to retain moisture, keeping your skin plumped and hydrated.

Vitamin B5 also helps to reduce inflammation, making it ideal for those with sensitive or acne-prone skin.

4. Hyaluronic Acid

Hyaluronic acid is a fantastic ingredient for hydration and is known for its ability to hold water in the skin, keeping it plump and smooth.

Vitamin C and hyaluronic acid work exceptionally well together because vitamin C brightens and protects, while hyaluronic acid hydrates and replenishes moisture.

If you have sensitive skin, hyaluronic acid can help mitigate any dryness or irritation caused by vitamin C, ensuring a more comfortable application.

Together, they leave the skin looking radiant, plump, and deeply hydrated.

Can You Mix Vitamin C and Niacinamide?

As we’ve already discussed, it’s best not to mix vitamin C and niacinamide in the same routine. These two ingredients can counteract each other’s benefits and lead to irritation.

However, you can still include both in your skincare routine by applying them at different times of the day or using them on alternate days.

For example, you can use vitamin C in the morning to protect against free radical damage, and apply niacinamide in the evening to hydrate, regulate oil production, and reduce the appearance of pores.

If you prefer using them on the same day, make sure to leave at least 10-15 minutes between applying each ingredient.

Can Vitamin C Be Used with Hyaluronic Acid?

Yes, vitamin C and hyaluronic acid can be used together, and in fact, they work wonderfully as a pair. Vitamin C can sometimes cause mild irritation, especially for those with sensitive skin.

When followed by a hydrating ingredient like hyaluronic acid, it can help soothe the skin and replenish moisture.

Hyaluronic acid helps to lock in moisture, keeping your skin plump, hydrated, and protected.

The combination of vitamin C’s brightening effects and hyaluronic acid’s moisture-boosting properties will leave your skin glowing, smooth, and radiant.

Does Vitamin C Cancel Out Retinol?

In short, yes, using vitamin C and retinol together can cause issues due to their different pH levels.

Both ingredients are potent, and when applied together, they can neutralize each other’s effects, resulting in skin irritation, dryness, and redness.

To avoid any negative reactions, apply vitamin C in the morning and retinol at night. This allows both ingredients to work effectively without interfering with one another.

Always follow up with sunscreen in the morning to protect your skin from UV damage, especially when using vitamin C.

What Comes First, Vitamin C or Hyaluronic Acid?

When applying both vitamin C and hyaluronic acid, start with the vitamin C serum.

Since vitamin C serums are typically thinner in consistency, they should be applied first, followed by a thicker serum or moisturizer like hyaluronic acid.

This ensures that the active ingredients in both products can be absorbed properly, and you’re left with a deeply hydrated and protected complexion.

Can Vitamin C Clog Pores?

While vitamin C is generally considered non-comedogenic, the form of vitamin C you use can impact whether it clogs pores.

Ascorbic acid, the most common form of vitamin C, can oxidize when exposed to air and light. This oxidation can lead to the formation of blackheads or clogged pores.

To avoid this, choose stabilized forms of vitamin C, such as ascorbyl tetraisopalmitate or sodium ascorbyl phosphate, which are less likely to oxidize.

Always store your vitamin C products in a cool, dark place to preserve their potency and prevent oxidation.

Conclusion

Now that you know what should and shouldn’t be mixed with vitamin C, you can confidently build a skincare routine that enhances your skin’s radiance and protects it from environmental damage.

Remember to avoid pairing vitamin C with ingredients like retinol, niacinamide, and AHAs/BHAs, and instead, combine it with ingredients like vitamin E, hyaluronic acid, and ferulic acid for maximum benefit.

As always, if you’re unsure about your skincare routine, consulting a dermatologist is a great idea to make sure you’re using the best combinations for your skin.

DQH Knowledge drop: In your 20s, your skin cell turnover decreases. (Cell turnover is a key component in keeping your skin youthful.) You know what else slows down? Your collagen production. Starting in your 20s, collagen decreases by about 1 percent per year. Should you want to prevent fine lines and wrinkles, start by eliminating behaviors that contribute to premature aging. “If it’s bad for you, it’s bad for your skin,” says dermatologist Michel Somenek. “Cigarette smoking reduces blood flow to the skin and causes premature wrinkling and a dull skin texture. Making the repeated pursed motion to inhale can also cause smoker’s lines. Alcohol and recreational drugs are toxins for the skin that damage its cellular structure and DNA,” Somenek tells us. “The faster you eliminate vices while you are young, the better chance your skin and body have to recuperate.” Also, adopting an anti-aging routine in your 20s is key. After all, the best offense is a good defense. We spoke to Somenek and experts Joshua Ross and Audrey Kunin to find out more. Keep reading for the best anti-aging products for your 20s, according to skincare professionals. Sunscreen “We all know that the sun is the number one cause of skin aging and starting the prevention in your 20s is very important,” Ross says. “The majority of your sun damage won’t start to appear until you’re in your 30s, so don’t wait until you see it surface or you’ll be behind the curve. Stay ahead of it with a good-quality zinc-based sunscreen worn daily.” Farmacy Green Defense Daily Mineral Sunscreen An invisible sunscreen with SPF 30, plus botanical extracts meant to protect skin with tons of antioxidants. Bonus: It’s clean and fine to use under makeup. Bareminerals Complexion Rescue™ Tinted Moisturizer Broad Spectrum SPF 30 Although we recommend you use your SPF and moisturizer separately, we also understand moments when you don’t have time or energy for that extra step. For those times, this bareMinerals moisturizer is a great thing to have on hand. Vitamin C Serum “A great introduction to anti-aging is to start with a vitamin C serum in your morning skincare routine,” Ross says. “It’s a powerful antioxidant that will neutralize free radicals and brighten the skin.” He adds that it’s a great way to counteract the effects of the sun’s harmful rays, which, as previously mentioned, are among the biggest causes of premature aging. Drunk Elephant C-Firma™ Vitamin C Day Serum The Drunk Elephant C-Firma is a lightweight serum that promises to give skin a glow by combining the brightening powers of vitamin C with ferulic acid, l-ascorbic acid, and vitamin E. The included sodium hyaluronate is meant to replace hydration loss, so you shouldn’t have to deal with any irritation. Sunday Riley C.E.O. Rapid Flash Brightening Serum This potent serum is jam-packed with vitamin C (15 percent, to be exact), which means it’s a potential superstar at both brightening skin and dousing it in antioxidants. Peptides Using peptides on your skin has many benefits, says Somenek. “The skin barrier is what defends the body against pollution, UV rays, bacteria, and toxins. It can be damaged by several everyday factors. Using topical peptides aids in building a stronger barrier,” he says. “Peptides comprise elastic fibers, which are a type of protein. These fibers help to make skin appear taut and firm. Peptides can also help repair damaged skin, relieve inflammation, and even out skin tone. Some peptides can kill acne-causing bacteria that is common in 20-somethings.” Kunin agrees, saying, “Peptides are an excellent entry point for supporting collagen.” She recommends looking for face and eye treatments that contain these collagen-boosting powerhouses. Charlotte Tilbury Magic Eye Rescue Cream This Charlotte Tilbury super-emollient eye cream has a base of coconut oil and shea butter (read: it’s incredibly hydrating). Botanicals plus peptides are meant to help reduce dark circles and boost collagen, respectively. This creamy moisturizer serves up potent collagen-boosting peptides and pycnogenol, and antioxidant-rich vitamin C. “Instead of sitting on top of the skin, peptides penetrate the outer layer so they go deep. The ‘signals’ they send tell the cells to produce elastin and collagen, which are needed for youthful-looking skin,” explains Somenek. At-Home Peel Pads Remember that skin cell turnover fiasco we talked about earlier? One way to help support it is by exfoliating. “Exfoliation is important to help keep skin fresh and luminous,” Kunin says. She recommends using at-home peel pads as an easy and effective way to exfoliate. “The goal in your 20s is to fight the slowing pace of cell turnover. It is wise to use products that gently exfoliate, yet still remove oil and other impurities. Products that have Alpha Hydroxy Acids (AHA) or Beta Hydroxy Acids (BHA) are a good choice.” According to Somenek, you should only exfoliate two to three times a week. “People of all ages are guilty of over-exfoliating and that can be too much of a good thing,” he says. Dermadoctor Kakadu C Intensive Vitamin C Peel Pad A few swipes of this Derma Doctor powerful peel pad promise to leave your skin glowing and smooth, thanks to the seven (yes, seven) types of chemical exfoliants, including AHA and BHA. It also contains vitamin C via Kakadu plum extract for added brightening and antioxidant protection. KEY INGREDIENTS Kakadu plum extract is sourced from the Kakadu plum, a fruit grown in northern Australia. It contains vitamin C, which restores the skin’s natural barrier, increases collagen production, and soothes irritation. Dr. Dennis Gross Skincare Alpha Beta® Universal Daily Peel Pads These are the gold standard of peel pads, with a cult following and over 900 five-star reviews on Sephora. They’re easy to use and contain a blend of anti-aging exfoliating acids. Emollient Night Cream “In your 20s, you need to start upping the hydration in your skincare routine. You may have been cautious of over-moisturizing because of acne in your teens, but as you enter your 20s, your skin transitions and becomes drier,” Ross says. “I recommend an emollient night cream added into your evening skincare regimen.” “Twenty-somethings need to make sure that they are not using creams that will clog their pores and cause excess oil production,” says Somenek. Opt for non-comedogenic products. Cerave Skin Renewing Night Cream One great choice is the CeraVe Skin Renewing Night Cream, which is a non-comedogenic night cream that leaves skin soft and glowy. It combines the moisturizing powers of ceramides and hyaluronic acid. RoC Retinol Correxion Max Hydration Creme “The best night cream ingredients contain retinol, benzoyl peroxide, and/or salicylic acid or hyaluronic acid. The goal is to moisturize, yet remove excess oil,” says Somenek. This Roc Retinol Correxion cream fits the bill as it contains both hyaluronic acid and retinol so it promises to moisturize while also being non-comedogenic.
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