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Skincare Products You Should Never Refrigerate: A Guide
Skin Care

Skincare Products You Should Never Refrigerate: A Guide

11 June 2025


Which Skincare Products Should Not Be Refrigerated?

As a dermatologist, one of the most common questions I encounter is whether or not certain skincare products should be stored in the refrigerator.

This question became especially frequent during the rise of skin care refrigerators as a trend.

Additionally, it’s a concern that comes up during winter months, particularly when my patients are traveling to colder regions and wonder whether leaving their skincare products or sunscreens in their cars would affect their efficacy.

While I’m based in Miami where the weather is generally warm, the use of skincare refrigerators has grown in popularity even here, so it’s a topic I often discuss.

When considering whether to refrigerate your skincare products, it’s important to understand that while cold temperatures can help extend the shelf life of some ingredients like vitamin C or retinol,

not all products are suited for refrigeration.

In fact, cooling certain formulas may cause them to thicken or, even worse, destabilize, causing them to lose their effectiveness faster than if they were stored at room temperature.

So, which skincare products should you avoid refrigerating? As a general rule, creams and oils don’t fare well in the cold.

However, there are also specific ingredients that don’t respond well to lower temperatures, and I’ll be addressing these in greater detail as we go along.

The Refrigerator Debate: Should You Refrigerate Your Skincare Products?

Many people choose to stock up on skincare products when they find a good sale. They may wonder whether refrigerating these products can help extend their expiration dates.

While refrigeration is sometimes a viable option, it’s not the best choice for every product.

How to Store Skincare Products: General Guidelines

To get the longest shelf life out of your serums, moisturizers, and other skincare products, proper storage conditions are essential.

However, the optimal storage method really depends on the specific types of ingredients present in each product.

For example, a serum packed with antioxidants may react well to being chilled, while a ceramide-based cream could be damaged by low temperatures.

To understand the best storage method for each product, it’s helpful to know the reactions of different ingredient categories.

First and foremost, always check the product packaging. Most skincare brands will provide clear storage recommendations, including a suggested temperature range.

However, not all products will include such guidance. If you don’t see specific instructions, room temperature (around 15-25°C or 59-77°F) should be your default.

When in doubt, consider how the active ingredients within each product respond to temperature.

For instance, antioxidants like vitamin C and retinoids benefit from being chilled to slow down their natural breakdown due to heat and light exposure.

On the other hand, products containing lipids, such as oils and fatty alcohols, can suffer when exposed to cold temperatures.

These can solidify or undergo texture changes that ruin the consistency of the product.

Refrigerator Temperature: Too Cold for Some Products

The typical temperature range for a refrigerator is between 35 and 38°F (1.6-3.3°C). While slightly warmer settings may reach 40°F (4.4°C), this is still too cold for many skincare products.

Freezer Temperature: A Big No for Skincare

Freezer temperatures typically fall between -10 and 0°F (-23 to -18°C). Storing skincare products in the freezer should be avoided at all costs. Such low temperatures can lead to several problems:

Texture Changes: Many moisturizers will become so thick that they are difficult to apply. In some cases, they may even freeze.

Separation: Some products contain multiple ingredients that can separate or lose their uniformity when exposed to extreme cold.

Altered Efficacy: The active ingredients in some products may lose their potency or effectiveness when subjected to freezing temperatures.

Packaging Issues: The packaging itself can be affected by extreme cold. For example, plastic tubes and bottles may become brittle and crack, leading to leaks or contamination.

Products You Should Never Refrigerate

Here’s a list of skincare products that should never be refrigerated, as they are particularly susceptible to destabilization or texture changes:

Exosome Serums: Exosomes are tiny vesicles released by cells and are believed to have anti-aging properties. Refrigeration can negatively affect their stability.

Growth Factor Serums: Similar to exosome serums, growth factor-based products rely on delicate proteins that can break down if exposed to cold.

Peptide Serums: Peptides are fragile and can lose their efficacy in low temperatures. These products should be stored at room temperature to maintain their full potential.

Some other products, such as face creams, body creams, and lotions, can be refrigerated, but they may change in texture or even separate when subjected to very low temperatures.

It’s also a good idea to warm them up to room temperature before application to ensure smooth and effective use.

Storing Moisturizers, Ointments, and Lotions

When it comes to products like moisturizers, creams, and oils, refrigeration is usually not the best option for long-term storage.

Most creams and lotions rely on a delicate balance of oil and water, stabilized by emulsifiers and thickeners. Cold temperatures can disrupt this balance, leading to separation or changes in texture.

For example, when oil-in-water emulsions are chilled, they tend to become thicker and harder to spread. Conversely, water-in-oil creams risk separating.

Instead of refrigeration, it’s generally best to store these products in a cool, dark place away from heat and light, such as a closet.

The bathroom is often too warm and humid for long-term skincare storage.

Organic Skincare and the Fridge

Organic skincare products, which are often preservative-free, may not fare as well when stored for extended periods without refrigeration.

If you have organic skincare and won’t be using it for more than a few months, temporarily storing it in the fridge can help prevent microbial growth.

However, long-term storage in the fridge can alter the texture. Ideally, you should buy organic skincare fresh when you plan to use it, rather than stockpiling.

Ceramides and Lipids: Avoiding the Cold

Ceramides, fatty acids, and lipids are often used in moisturizers and barrier repair creams.

These ingredients are highly sensitive to cold temperatures and will solidify, crystallize, or break down when exposed to refrigeration.

Ceramides are waxy lipids that reinforce the skin’s moisture barrier.

When they’re exposed to cold, they tend to thicken and may even crystallize, leading to changes in the texture of the cream or serum.

Similarly, fatty acids, which are found in heavier creams, can solidify at lower temperatures. Saturated fatty acids, such as stearic and palmitic acid, are especially prone to this change.

Unsaturated fatty acids, on the other hand, can tolerate refrigeration better, but they still need to be allowed to return to room temperature before application.

Fatty Alcohols: Storing With Care

Fatty alcohols like cetyl alcohol and cetearyl alcohol are often used in skincare to thicken products and create smooth textures. Unfortunately, these alcohols also respond poorly to cold.

When exposed to low temperatures, they solidify, which can ruin the texture of creams and lotions. This is especially problematic for products that rely on these alcohols to maintain their consistency.

Retinol, Vitamin C, and Other Sensitive Ingredients

Certain ingredients are highly sensitive to temperature fluctuations. Retinol (and its derivatives like tretinoin) is one example.

This powerful anti-aging ingredient is highly unstable when exposed to light, heat, or air. Refrigeration can actually extend its potency, but freezing can destroy it completely.

Similarly, vitamin C (ascorbic acid) is highly prone to oxidation. Keeping it in the fridge can prevent this degradation, although newer formulations may not need refrigeration.

Hyaluronic acid, another common skincare ingredient, remains stable across a wide range of temperatures. However, refrigerating it can cause lower-quality formulations to thicken and become difficult to apply.

Sunscreens: Should You Refrigerate Them?

Sunscreens are best kept in a cool, dry place, away from direct sunlight. Extreme temperatures, whether hot or cold, can affect their stability.

Mineral sunscreens, which contain ingredients like zinc oxide or titanium dioxide, don’t need refrigeration, but storing them in the fridge may thicken the formula without improving its longevity.

On the other hand, chemical sunscreens may benefit from refrigeration, especially if they contain organic UV filters that degrade more quickly at higher temperatures.

Toners: To Chill or Not to Chill?

Alcohol-based toners are generally safe to refrigerate, as alcohol tends to mix well with water, even in cold conditions. However, non-alcoholic toners may become too thick when chilled.

Cold toners can feel refreshing, but it’s worth noting that cold temperatures can inhibit the absorption of other products applied afterward.

Ointments: Room Temperature Is Best

Ointments like Vaseline, Aquaphor, and antibiotic creams contain ingredients such as petroleum jelly and mineral oil, which are best stored at room temperature.

Storing them in the fridge makes them hard to spread and difficult to use.

Conclusion

In conclusion, the decision to refrigerate skincare products depends on the specific ingredients and the type of product.

While certain active ingredients like retinol and vitamin C benefit from refrigeration, many others, especially those containing lipids and fatty alcohols, do not.

For most skincare, a cool, dark place at room temperature is the optimal storage condition.

If you’re unsure about a particular product, always refer to the manufacturer’s storage recommendations to ensure it remains effective.

Let us help you find the best skincare products for your skin type!

DQH Knowledge drop: In your 20s, your skin cell turnover decreases. (Cell turnover is a key component in keeping your skin youthful.) You know what else slows down? Your collagen production. Starting in your 20s, collagen decreases by about 1 percent per year. Should you want to prevent fine lines and wrinkles, start by eliminating behaviors that contribute to premature aging. “If it’s bad for you, it’s bad for your skin,” says dermatologist Michel Somenek. “Cigarette smoking reduces blood flow to the skin and causes premature wrinkling and a dull skin texture. Making the repeated pursed motion to inhale can also cause smoker’s lines. Alcohol and recreational drugs are toxins for the skin that damage its cellular structure and DNA,” Somenek tells us. “The faster you eliminate vices while you are young, the better chance your skin and body have to recuperate.” Also, adopting an anti-aging routine in your 20s is key. After all, the best offense is a good defense. We spoke to Somenek and experts Joshua Ross and Audrey Kunin to find out more. Keep reading for the best anti-aging products for your 20s, according to skincare professionals. Sunscreen “We all know that the sun is the number one cause of skin aging and starting the prevention in your 20s is very important,” Ross says. “The majority of your sun damage won’t start to appear until you’re in your 30s, so don’t wait until you see it surface or you’ll be behind the curve. Stay ahead of it with a good-quality zinc-based sunscreen worn daily.” Farmacy Green Defense Daily Mineral Sunscreen An invisible sunscreen with SPF 30, plus botanical extracts meant to protect skin with tons of antioxidants. Bonus: It’s clean and fine to use under makeup. Bareminerals Complexion Rescue™ Tinted Moisturizer Broad Spectrum SPF 30 Although we recommend you use your SPF and moisturizer separately, we also understand moments when you don’t have time or energy for that extra step. For those times, this bareMinerals moisturizer is a great thing to have on hand. Vitamin C Serum “A great introduction to anti-aging is to start with a vitamin C serum in your morning skincare routine,” Ross says. “It’s a powerful antioxidant that will neutralize free radicals and brighten the skin.” He adds that it’s a great way to counteract the effects of the sun’s harmful rays, which, as previously mentioned, are among the biggest causes of premature aging. Drunk Elephant C-Firma™ Vitamin C Day Serum The Drunk Elephant C-Firma is a lightweight serum that promises to give skin a glow by combining the brightening powers of vitamin C with ferulic acid, l-ascorbic acid, and vitamin E. The included sodium hyaluronate is meant to replace hydration loss, so you shouldn’t have to deal with any irritation. Sunday Riley C.E.O. Rapid Flash Brightening Serum This potent serum is jam-packed with vitamin C (15 percent, to be exact), which means it’s a potential superstar at both brightening skin and dousing it in antioxidants. Peptides Using peptides on your skin has many benefits, says Somenek. “The skin barrier is what defends the body against pollution, UV rays, bacteria, and toxins. It can be damaged by several everyday factors. Using topical peptides aids in building a stronger barrier,” he says. “Peptides comprise elastic fibers, which are a type of protein. These fibers help to make skin appear taut and firm. Peptides can also help repair damaged skin, relieve inflammation, and even out skin tone. Some peptides can kill acne-causing bacteria that is common in 20-somethings.” Kunin agrees, saying, “Peptides are an excellent entry point for supporting collagen.” She recommends looking for face and eye treatments that contain these collagen-boosting powerhouses. Charlotte Tilbury Magic Eye Rescue Cream This Charlotte Tilbury super-emollient eye cream has a base of coconut oil and shea butter (read: it’s incredibly hydrating). Botanicals plus peptides are meant to help reduce dark circles and boost collagen, respectively. This creamy moisturizer serves up potent collagen-boosting peptides and pycnogenol, and antioxidant-rich vitamin C. “Instead of sitting on top of the skin, peptides penetrate the outer layer so they go deep. The ‘signals’ they send tell the cells to produce elastin and collagen, which are needed for youthful-looking skin,” explains Somenek. At-Home Peel Pads Remember that skin cell turnover fiasco we talked about earlier? One way to help support it is by exfoliating. “Exfoliation is important to help keep skin fresh and luminous,” Kunin says. She recommends using at-home peel pads as an easy and effective way to exfoliate. “The goal in your 20s is to fight the slowing pace of cell turnover. It is wise to use products that gently exfoliate, yet still remove oil and other impurities. Products that have Alpha Hydroxy Acids (AHA) or Beta Hydroxy Acids (BHA) are a good choice.” According to Somenek, you should only exfoliate two to three times a week. “People of all ages are guilty of over-exfoliating and that can be too much of a good thing,” he says. Dermadoctor Kakadu C Intensive Vitamin C Peel Pad A few swipes of this Derma Doctor powerful peel pad promise to leave your skin glowing and smooth, thanks to the seven (yes, seven) types of chemical exfoliants, including AHA and BHA. It also contains vitamin C via Kakadu plum extract for added brightening and antioxidant protection. KEY INGREDIENTS Kakadu plum extract is sourced from the Kakadu plum, a fruit grown in northern Australia. It contains vitamin C, which restores the skin’s natural barrier, increases collagen production, and soothes irritation. Dr. Dennis Gross Skincare Alpha Beta® Universal Daily Peel Pads These are the gold standard of peel pads, with a cult following and over 900 five-star reviews on Sephora. They’re easy to use and contain a blend of anti-aging exfoliating acids. Emollient Night Cream “In your 20s, you need to start upping the hydration in your skincare routine. You may have been cautious of over-moisturizing because of acne in your teens, but as you enter your 20s, your skin transitions and becomes drier,” Ross says. “I recommend an emollient night cream added into your evening skincare regimen.” “Twenty-somethings need to make sure that they are not using creams that will clog their pores and cause excess oil production,” says Somenek. Opt for non-comedogenic products. Cerave Skin Renewing Night Cream One great choice is the CeraVe Skin Renewing Night Cream, which is a non-comedogenic night cream that leaves skin soft and glowy. It combines the moisturizing powers of ceramides and hyaluronic acid. RoC Retinol Correxion Max Hydration Creme “The best night cream ingredients contain retinol, benzoyl peroxide, and/or salicylic acid or hyaluronic acid. The goal is to moisturize, yet remove excess oil,” says Somenek. This Roc Retinol Correxion cream fits the bill as it contains both hyaluronic acid and retinol so it promises to moisturize while also being non-comedogenic.
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