Argiriline in Skin Care Products

Argiriline

Argiriline is one of the most popular skin care peptides because it was originally advertised to be better than Botox.

Argiriline has been shown to have short term skin benefits and has interesting effects on cells in the laboratory which is why it has been compared to Botox.

However, when used in face creams and serums, argiriline cannot permeate the skin layers to reach the muscle and relax muscles like Botox can -so Argiriline in no way is a replacement for Botox injections.

How does Argiriline work on skin? Is it Effective?

This cosmeceutical peptide works by copying another molecule called SNAP-25 and breaks up a group of molecules called the SNARE complex.

SNAP-25 in the SNARE complex is the same target for Botulinum Toxin Type A (Botox, Dysport, Xeomin, Jeaveau, Daxxify).

Some companies used to say that skin care products with Argiriline are “Better than Botox” . (They actually got away with making that false claim by adding a question mark so that instead of a claim it was actually a question “Better than Botox?”. )

The problem with Argiriline and other peptides is that it does not penetrate deep enough into the skin’s layers to have an effect.

Studies on this peptide were done in cell cultures where skin penetration is not an issue.

Peptides do not absorb through the skin into the muscle to relax muscles the same way Botox does.

This is why Argiriline does not have the same benefits as Botox, Dysport and other forms of Botulinum Toxin Type A.(1)

Benefits of argiriline

Other names for Argiriline

Argiriline is also called Acetyl Hexapeptide-8 and Acetyl Hexapeptide-3.

Argiriline® is made up of these : Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2.

This sequence includes multiple amino acids joined together by peptide bonds. The peptide begins with an acetyl group (Ac-) and ends with an amide group (-NH2), which are common modifications to peptides.

The structure of this molecule may also be stated like this: Acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2 or Ac?EEMQRR?NH2.

Studies on Argiriline (Acetyl Hexapeptide-8)

There are some studies that assessed Argiriline containing creams and their benefits.

One study (2) looked at ten women who used a topical ream with 10% acetyl hexapeptide-3 and compared it to a cream without Argiriline (called the vehicle).

They put the creams on the area around the eyes twice a day for 30 days.

The study did not say if the people doing the study or the women in the study knew which cream was which. If this were a blinded study, they would have stated that in the research publication. Not using a blinded research method allows bias to affect study results.

The scientists looked at the wrinkles on the women’s skin before and after using the creams. Women who used the cream with Argiriline had 30% fewer wrinkles than before.

But they also said that the women who used the vehicle cream had 10% fewer wrinkles than before.

It is not very clear if the difference between these two numbers is statistically significant, if they were the research publication would state that clearly because that sit h goal of research studies to show statistical significance.

The study also showed by looking at excised epidermis that acetyl hexapeptide-3 can go through the top layer of skin. But to get to the muscles where it could mess with the SNARE complex, it would also have to go through other layers of skin, which the study did not look at.

Another study (3) was conducted in 2015 on acetyl hexapeptide-3 with 40 female participants. It was not clear from the publication whether the participants and investigators were blinded.

The study cream or vehicle was applied twice daily by both groups to the forearm and face.

Both the active and the vehicle showed increased hydration. The reviscometer measurements of shear wave propagation showed a decrease in skin anisotropy, but only on the face, suggesting that the peptides increased skin firmness. There was no improvement in skin elasticity as measured with a cutometer.

The authors concluded that “acetyl hexapeptide-3 is an effective anti-aging compound,” but they did not consider the possibility that accumulated peptides on the skin’s surface could affect firmness without affecting the skin’s biology.

Peptides are known to coat the skin’s surface giving a feeling or firmness which disappears when the cream is washed off.

botox vs argiriline

A study (4) in 2017 examined a combination of two peptides (tripeptide-10-citrulline and acetyl hexapeptide-3) on 24 women to see if it could improve skin roughness. The participants were split into four groups: one group used both peptides, one group used only tripeptide-10-citrulline, one group used only acetyl hexapeptide-3, and the last group used a placebo. The study measured skin roughness and found no significant difference between the placebo group and the groups using the peptides after 20 and 40 days. However, after 60 days, there was a significant difference between the placebo group and the group using both peptides (including argiriline). The study suggested that the peptides can reduce TEWL (transepidermal water loss) by forming a protective film on the skin’s surface. However, the study did not consider wrinkle depth, only skin roughness, and the presentation of the data in the abstract was confusing and lacked transparency. Therefore, the study’s claim that the peptides can reduce wrinkle depth is questionable.

How does Argiriline compare to other antiaging skin care ingredients?

Argiriline is not as good as retinol, ascorbic acid, exosomes and growth factors to treat wrinkles.

Ingredients like argiriline are best used in addition to other ingredients for maximum effect.

Is Argiriline better than retinol?

NO, argiriline is not the best – retinol and retinoids are the best antiaging skin creams.

There are many types and strengths and must be used properly to prevent side effects.

But retinoids are worth using because studies have shown they treat many of the causes of wrinkles.

Argiriline does not treat any of the causes of skin aging.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

Related Articles

Ad Blocker Detected