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Azelaic Acid vs Benzoyl Peroxide for Acne Similarities, Differences and How To Choose Between The Two
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Azelaic Acid vs Benzoyl Peroxide for Acne Similarities, Differences and How To Choose Between The Two

13 November 2024






Azelaic Acid vs. Benzoyl Peroxide for Acne Treatment: Similarities, Differences, and How to Choose Between Them



Azelaic acid and benzoyl peroxide are two ingredients commonly recommended for acne-prone skin, but how do they differ? Is one more effective than the other?





Learn about the similarities and differences between the two substances and how to determine which one is right for you.



What is Azelaic Acid?





Azelaic acid is a dicarboxylic acid found in grains such as wheat, barley, and rye. It has antimicrobial and anti-inflammatory properties, making it a common choice for treating acne, hyperpigmentation, rosacea, and mild skin irritations. Azelaic acid also has powerful antioxidant effects that help neutralize free radicals that cause environmental damage to all skin types, including sensitive skin. With its antimicrobial and anti-inflammatory effects, the naturally occurring acid helps eliminate acne-causing bacteria on the skin while breaking the link between elevated testosterone levels and other hormonal changes, thereby minimizing hormonal breakouts.



Benefits of Azelaic Acid





The benefits of Azelaic Acid include:



Clinically proven to reduce acne1





Clinically proven to reduce rosacea lesions2



Relieves irritation and redness





Kills bacteria on the skin, reducing and healing acne breakouts



Brightens complexion





Opens clogged pores and removes dead skin cells



Improves skin texture





Reduces fine lines and wrinkles



Lightens acne scars and hyperpigmentation





Minimizes hormonal breakouts



Gentle enough for sensitive skin





What is Benzoyl Peroxide?



Benzoyl peroxide is a topical antiseptic that treats acne by releasing free radicals into the skin to kill acne-causing bacteria. It has mild sebum-inhibiting and keratolytic properties, meaning it inhibits excess oil production and dissolves skin flakes and lesions. 3 These actions help clear acne, but can cause dry and flaky skin. Like azelaic acid, benzoyl peroxide is a powerful anti-inflammatory agent that helps reduce redness and irritation, as well as other skin conditions like rosacea.





Benzoyl Peroxide Benefits



Benefits of benzoyl peroxide include:





Clinically proven to reduce acne4



Clinically proven to reduce rosacea lesions5





Soothes inflamed skin



Controls oil production





Clears clogged pores

Exfoliates dead skin cells

Azelaic Acid vs. Benzoyl Peroxide

Clinical studies have shown that topical azelaic acid is just as effective as benzoyl peroxide and other popular acne treatments, such as topical retinoids, erythromycin, and oral tetracycline, in reducing acne.6 However, azelaic acid is known to be much gentler on the skin than other products, is less harsh on the skin, does not cause peeling or irritation, and does not make the skin more sensitive to the sun.

Discover more similarities and differences between azelaic acid and benzoyl peroxide below.

Azelaic Acid 14% Cream

Azelaic Acid 14% Cream

• Reduces acne and rosacea

• Brightens skin tone and fades brown spots

• Unclogs pores and improves skin texture

Regular Price $45

Add to Cart

Similarities

Azelaic Acid and Benzoyl Peroxide:

Clinically proven to reduce acne and rosacea

Have antimicrobial properties, killing bacteria on the skin

Exfoliates, unclogs pores, removes dead skin cells

Relieves inflammation, reduces redness and swelling

Differences

They appear to work the same, but what is the difference between azelaic acid and benzoyl peroxide? Quite a few, it turns out. Although azelaic acid shares similarities with acne and has been shown to be effective in treating acne, azelaic acid is considered gentler, making it a suitable choice for those with sensitive skin. Benzoyl peroxide is known to cause flaking and irritation, and can dry out the skin when trying to prevent excess oil. The ingredient also has bleaching properties, which can affect hair and clothing if used incorrectly. You are more susceptible to sun damage when using benzoyl peroxide, so it is important to use sunscreen and protective clothing or avoid sun exposure.

Another important difference between azelaic acid and benzoyl peroxide is that azelaic acid promotes the skin’s cell renewal process and stimulates collagen production to heal and repair damaged skin. Azelaic acid is also an antioxidant, which means it reduces free radicals in the skin. For these reasons, azelaic acid can be used to reduce fine lines and wrinkles. On the other hand, benzoyl peroxide actually promotes free radicals in the skin, and repeated use may cause sunburn-like changes in the skin. 7

Can Azelaic Acid and Benzoyl Peroxide Be Used Together?

There may be benefits from using azelaic acid and benzoyl peroxide together. Some studies show that using azelaic acid and benzoyl peroxide together is actually more effective than using benzoyl peroxide alone. 8

Due to its antioxidant properties, using azelaic acid can also counteract or neutralize the potential damage of free radicals released by benzoyl peroxide.

When and how should you use azelaic acid compared to benzoyl peroxide?

Both azelaic acid and benzoyl peroxide can be used once or twice daily, depending on your skin type and condition. When using both ingredients together, it is recommended to cleanse the skin first, moisturize, apply benzoyl peroxide first, and apply azelaic acid last. Whether you use azelaic acid or benzoyl peroxide or both, always use an SPF 30 or higher sunscreen afterwards. Although azelaic acid offers stronger protection and will not make you more sensitive to the sun, it is still recommended that you use a sunscreen to protect your skin and health.

Developed by dermatologists and chemists, Base Skincare Azelaic Acid 14% Cream has the highest over-the-counter azelaic acid content. Formulated with a moisturizer base, this product layers well with other ingredients without causing irritation or pilling. It is especially useful when used with drying ingredients like benzoyl peroxide because it can help moisturize the skin.

Other products you may want to add to your acne treatment routine include FS Niacinamide Lotion 10% (to soothe skin and aid DNA repair), FS Hyaluronic Acid Lotion (to lock in moisture), and Night Renewal Cream with 2% Granactive™ Retinoid (to improve overall texture).

Key Insights

In summary, azelaic acid is good for acne, but so is benzoyl peroxide. Both kill acne-causing bacteria on the skin, reduce inflammation, and open clogged pores while removing dead skin cells. However, when it comes to the differences between azelaic acid and benzoyl, there are some important distinctions to remember: Azelaic acid is a powerful antioxidant, while benzoyl peroxide promotes the production of free radicals in the skin. While azelaic acid is gentle enough to be used on the most sensitive skin, benzoyl peroxide may cause flaking and redness and may dry out the skin.

If you’re still unsure which product to use, we recommend starting with azelaic acid as a gentler option. Then, if you need more help, you can also use benzoyl peroxide as a spot treatment along with other acne-fighting ingredients in your basic skincare line.

DQH Knowledge drop: In your 20s, your skin cell turnover decreases. (Cell turnover is a key component in keeping your skin youthful.) You know what else slows down? Your collagen production. Starting in your 20s, collagen decreases by about 1 percent per year. Should you want to prevent fine lines and wrinkles, start by eliminating behaviors that contribute to premature aging. “If it’s bad for you, it’s bad for your skin,” says dermatologist Michel Somenek. “Cigarette smoking reduces blood flow to the skin and causes premature wrinkling and a dull skin texture. Making the repeated pursed motion to inhale can also cause smoker’s lines. Alcohol and recreational drugs are toxins for the skin that damage its cellular structure and DNA,” Somenek tells us. “The faster you eliminate vices while you are young, the better chance your skin and body have to recuperate.” Also, adopting an anti-aging routine in your 20s is key. After all, the best offense is a good defense. We spoke to Somenek and experts Joshua Ross and Audrey Kunin to find out more. Keep reading for the best anti-aging products for your 20s, according to skincare professionals. Sunscreen “We all know that the sun is the number one cause of skin aging and starting the prevention in your 20s is very important,” Ross says. “The majority of your sun damage won’t start to appear until you’re in your 30s, so don’t wait until you see it surface or you’ll be behind the curve. Stay ahead of it with a good-quality zinc-based sunscreen worn daily.” Farmacy Green Defense Daily Mineral Sunscreen An invisible sunscreen with SPF 30, plus botanical extracts meant to protect skin with tons of antioxidants. Bonus: It’s clean and fine to use under makeup. Bareminerals Complexion Rescue™ Tinted Moisturizer Broad Spectrum SPF 30 Although we recommend you use your SPF and moisturizer separately, we also understand moments when you don’t have time or energy for that extra step. For those times, this bareMinerals moisturizer is a great thing to have on hand. Vitamin C Serum “A great introduction to anti-aging is to start with a vitamin C serum in your morning skincare routine,” Ross says. “It’s a powerful antioxidant that will neutralize free radicals and brighten the skin.” He adds that it’s a great way to counteract the effects of the sun’s harmful rays, which, as previously mentioned, are among the biggest causes of premature aging. Drunk Elephant C-Firma™ Vitamin C Day Serum The Drunk Elephant C-Firma is a lightweight serum that promises to give skin a glow by combining the brightening powers of vitamin C with ferulic acid, l-ascorbic acid, and vitamin E. The included sodium hyaluronate is meant to replace hydration loss, so you shouldn’t have to deal with any irritation. Sunday Riley C.E.O. Rapid Flash Brightening Serum This potent serum is jam-packed with vitamin C (15 percent, to be exact), which means it’s a potential superstar at both brightening skin and dousing it in antioxidants. Peptides Using peptides on your skin has many benefits, says Somenek. “The skin barrier is what defends the body against pollution, UV rays, bacteria, and toxins. It can be damaged by several everyday factors. Using topical peptides aids in building a stronger barrier,” he says. “Peptides comprise elastic fibers, which are a type of protein. These fibers help to make skin appear taut and firm. Peptides can also help repair damaged skin, relieve inflammation, and even out skin tone. Some peptides can kill acne-causing bacteria that is common in 20-somethings.” Kunin agrees, saying, “Peptides are an excellent entry point for supporting collagen.” She recommends looking for face and eye treatments that contain these collagen-boosting powerhouses. Charlotte Tilbury Magic Eye Rescue Cream This Charlotte Tilbury super-emollient eye cream has a base of coconut oil and shea butter (read: it’s incredibly hydrating). Botanicals plus peptides are meant to help reduce dark circles and boost collagen, respectively. This creamy moisturizer serves up potent collagen-boosting peptides and pycnogenol, and antioxidant-rich vitamin C. “Instead of sitting on top of the skin, peptides penetrate the outer layer so they go deep. The ‘signals’ they send tell the cells to produce elastin and collagen, which are needed for youthful-looking skin,” explains Somenek. At-Home Peel Pads Remember that skin cell turnover fiasco we talked about earlier? One way to help support it is by exfoliating. “Exfoliation is important to help keep skin fresh and luminous,” Kunin says. She recommends using at-home peel pads as an easy and effective way to exfoliate. “The goal in your 20s is to fight the slowing pace of cell turnover. It is wise to use products that gently exfoliate, yet still remove oil and other impurities. Products that have Alpha Hydroxy Acids (AHA) or Beta Hydroxy Acids (BHA) are a good choice.” According to Somenek, you should only exfoliate two to three times a week. “People of all ages are guilty of over-exfoliating and that can be too much of a good thing,” he says. Dermadoctor Kakadu C Intensive Vitamin C Peel Pad A few swipes of this Derma Doctor powerful peel pad promise to leave your skin glowing and smooth, thanks to the seven (yes, seven) types of chemical exfoliants, including AHA and BHA. It also contains vitamin C via Kakadu plum extract for added brightening and antioxidant protection. KEY INGREDIENTS Kakadu plum extract is sourced from the Kakadu plum, a fruit grown in northern Australia. It contains vitamin C, which restores the skin’s natural barrier, increases collagen production, and soothes irritation. Dr. Dennis Gross Skincare Alpha Beta® Universal Daily Peel Pads These are the gold standard of peel pads, with a cult following and over 900 five-star reviews on Sephora. They’re easy to use and contain a blend of anti-aging exfoliating acids. Emollient Night Cream “In your 20s, you need to start upping the hydration in your skincare routine. You may have been cautious of over-moisturizing because of acne in your teens, but as you enter your 20s, your skin transitions and becomes drier,” Ross says. “I recommend an emollient night cream added into your evening skincare regimen.” “Twenty-somethings need to make sure that they are not using creams that will clog their pores and cause excess oil production,” says Somenek. Opt for non-comedogenic products. Cerave Skin Renewing Night Cream One great choice is the CeraVe Skin Renewing Night Cream, which is a non-comedogenic night cream that leaves skin soft and glowy. It combines the moisturizing powers of ceramides and hyaluronic acid. RoC Retinol Correxion Max Hydration Creme “The best night cream ingredients contain retinol, benzoyl peroxide, and/or salicylic acid or hyaluronic acid. The goal is to moisturize, yet remove excess oil,” says Somenek. This Roc Retinol Correxion cream fits the bill as it contains both hyaluronic acid and retinol so it promises to moisturize while also being non-comedogenic.
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