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Gentle Yet Powerful: How Lactobionic Acid Exfoliates Without Irritating Sensitive Skin
Beauty

Gentle Yet Powerful: How Lactobionic Acid Exfoliates Without Irritating Sensitive Skin

28 April 2025


Lactobionic Acid Will Gently Exfoliate Even the Most Sensitive Skin Types




While exfoliation is one of the best ways to remove dead skin cells and boost your glow, many physical and chemical exfoliants can be too harsh in practice—and that especially goes if you have sensitive skin. If your complexion seems to react at the mere sight of a nearby acid but you still could use a bit of rejuvenation, lactobionic acid is a gentler option that may be worth a try. Aside from its exfoliating properties, this ingredient also works to hydrate the skin and support the skin barrier, among other benefits (and all with minimal to no irritation). Ahead, dermatologists explain all you need to know about lactobionic acid, from its benefits to where it best fits into your routine.



Meet the Experts




Hannah Kopelman, MD, is a board-certified dermatologist at Kopelman Aesthetic Surgery in New York City.



Karyn Grossman, MD, is a board-certified dermatologist and cosmetic surgeon at Grossman Dermatology.




What Is Lactobionic Acid?



Lactobionic acid is an exfoliating and hydrating skincare ingredient that’s classified as a polyhydroxy acid (PHA). It comes from milk sugars and is known to be milder and more gentle on the skin than alpha-hydroxy acids (AHAs) and beta-hydroxy acids (BHAs).




“What I find so appealing about lactobionic acid is how gentle it is while still delivering real results,” says board-certified dermatologist Hannah Kopelman, MD. “It’s derived from lactose, which is a milk sugar, and that gentleness really sets it apart.”



Board-certified dermatologist and cosmetic surgeon Karyn Grossman, MD, explains that lactobionic acid has a larger molecular structure than AHAs and BHAs, which makes it less likely to deeply penetrate the skin, allowing for a gentler exfoliation process.




Benefits of Lactobionic Acid



Interested in giving lactobionic acid a try (or need a bit more convincing)? Below are a few ways this skincare ingredient can benefit your skin:




Gentle exfoliation: Lactobionic acid exfoliates and helps remove dead skin cells from the skin’s surface without being as harsh as some other types of skincare acids. This means it’s less likely to cause irritation, stinging, and burning sensations. “It works by loosening the bonds between dead skin cells, which helps promote cell turnover,” Kopelman says. “This can lead to smoother skin, fewer fine lines, and that radiant, healthy glow we all strive for.”



Hydration: People with dry skin can benefit from incorporating lactobionic acid into their skincare routine because of the ingredient’s hydrating properties. “One of the standout features of lactobionic acid is its ability to attract and retain moisture,” Grossman says. “It acts as a humectant, drawing water into the skin, which helps improve skin hydration and reduce dryness.”




Antioxidants: Lactobionic acid has antioxidant properties, which can protect your skin.1 “It helps protect your skin from free radicals—those pesky molecules that can cause premature aging,” Kopelman says. “By shielding your skin from oxidative stress, lactobionic acid helps maintain a youthful appearance.”



Supports the skin barrier: Lactobionic acid helps strengthen the skin’s barrier health. 1 “This makes it especially beneficial for those with compromised skin, whether it’s due to environmental factors or underlying conditions like eczema or rosacea,” Kopelman says.




Reduces appearance of fine lines: “By gently exfoliating the skin and enhancing moisture retention, lactobionic acid can minimize the appearance of fine lines and wrinkles, making the skin appear smoother and more plump,” Grossman says.



Who Should Use It




Lactobionic acid is suitable for many different skin types, though dermatologists say it can be a particularly good option for people with slightly sensitive skin or those who are new to exfoliation and nervous about irritating their complexion. “It’s such a gentle exfoliant that even those who can’t tolerate AHAs or BHAs can usually use it without any issues,” Kopelman says. “But really, almost anyone can benefit from lactobionic acid, whether you’re looking to smooth out your skin, add a bit more hydration, or protect against the signs of aging.” Because of lactobionic acid’s moisturizing properties, it can also be good for people with dry or dehydrated skin, Grossman tells us.



If you have an allergy to lactose or milk, be cautious about using lactobionic acid, given that it’s derived from lactose. As always, you should ask your dermatologist if you have any uncertainty about whether the ingredient seems safe for you to try.




How to Use It



Lactobionic acid may be significantly gentler than most exfoliants, but proper use is still important to ensure you get maximum benefits while keeping your skin happy. A few top tips to follow are below:




Let your skin adjust: The first rule of thumb, as with most skincare products, is to start slow. “When incorporating lactobionic acid into your skincare routine, start by using it two to three times a week, especially if you are new to exfoliants,” Grossman says. “This allows your skin to build tolerance. As your skin adjusts, you can increase usage to every other day or even daily, depending on your skin’s response.”



Keep your skin hydrated: After using lactobionic acid, it’s important to use a good moisturizer. “This helps seal in the moisture and keep your skin feeling soft and supple,” Kopelman says.




Wear plenty of SPF: Keep in mind that exfoliants like lactobionic acid can make your skin more sensitive to the sun, so you’ll need to be diligent about wearing sunscreen. “Make sure you’re applying sunscreen every day, even if it’s cloudy,” Kopelman says. “Protecting your skin from UV damage is crucial.”



Stick to nighttime use: Grossman suggests using lactobionic acid at night, since exfoliating products can make your skin more sensitive to the sun.




Be mindful of your routine: Grossman also suggests using caution when combining lactobionic acid with other strong exfoliants or retinoids. “I usually suggest that you use either a retinoid or an acid on a given evening,” Grossman says. “Those with very oily skin may tolerate a lactobionic acid toner followed by a retinoid, but this would need to be worked up to very gradually.”



Check for sensitivity: As with other skincare products, consider doing a patch test before incorporating lactobionic acid into your skincare routine. This gives you a chance to see how your skin responds to the product, and is especially important if your skin is reactive.




The Final Takeaway



Given lactobionic acid balances exfoliating and hydrating properties while being gentle on sensitive skin, it may just be the skincare ingredient you never knew you needed. Dermatologists say it works for most skin types, so while you should patch-test if you’re worried about a reaction, this is a good option to consider if you’re looking for a way to achieve a rejuvenated glow with minimal irritation.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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