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Gluconolactone: The Sensitive Skin Hero You Haven’t Tried Yet
Skin Care

Gluconolactone: The Sensitive Skin Hero You Haven’t Tried Yet

1 June 2025


What Does Gluconolactone do in Skincare and What are its Benefits?

Gluconolactone, you’ve probably never heard of it before and I wouldn’t blame you for groaning at the thought of having to learn about yet another chemical exfoliant.

But I would be lying if I said this clever PHA is one to pass by.

This under the radar skin ingredient carries with it a lot of oomph and you’ll be amazed with the difference in the appearance of your skin, especially with gluconolactone being hailed the gentlest acid available on the market.

So, what is it about this gentle skin giant that makes it really stand out from the crowd, well that’s exactly what we are going to explore today.

What is gluconolactone?

As a member of the PHA family, gluconolactone is known for being the gentlest of the chemical exfoliants and has one of the largest molecule size meaning it is unable to penetrate very deeply

into the skin making it the best option for those who have sensitive skin, who still want to slough away the build-up of dead skin cells.

With all its benefits, the chances of finding active levels of gluconolactone in skincare formulations is unlikely, compared to the AHA and BHA powerhouse ingredient, such as glycolic acid and salicylic acid.

Having said that gluconolactone provides impressive support for the active ingredients allowing the skin to be exfoliated as well as locking in moisture into the skin.

These hydrating properties alone mean that introducing the PHA into your daily routine will benefit your skin enabling it to look and feel healthier.

What are the skin benefits of gluconolactone?

You will find that gluconolactone is a multi-tasking ingredient offering countless skin benefits and helping you achieve an overall flawless complexion.

Here are some of the main benefits you can expect to find when introducing this PHA into your routine.

Offers antioxidant properties to the skin

Studies have shown that the antioxidant properties of gluconolactone do not compare to those found in other ingredients, such as vitamins C and E.

Having said that gluconolactone is praised at its abilities to neutralise free radicals and the damage they can cause to the skin.

It is also able to bind together the free radicals encapsulating the damage caused from exposure to the sun, pollution, central heating and other environmental stresses.

Exfoliates the skin

With gluconolactone being a PHA, it is able to provide exfoliation to the skin by dissolving the bounds holding the layer of dead skin cells to the outer surface of the skin.

If these cells are left to build-up it can result in flaky, dry patches, dull looking skin with uneven texture.

You may also find that breakouts such as spots and blackheads develop which can become severe depending on the skin type you have, oily skin for example, can suffer from more frequent blemishes due to the excess sebum found in the pores.

Quite often other skin types that are sensitive and dry cannot use any form of chemical exfoliation without experiencing some form of skin irritation.

However, as previously mentioned, gluconolactone is very gentle and much like all PHAs can be used by those with hyper-sensitive skin and skin concerns such as eczema and rosacea.

You may find that common side effects, such as redness and irritation won’t occur compared to more potent chemical exfoliants such as glycolic and salicylic acid.

Hydrates the skin

One of the properties that make PHAs such as gluconolactone unique is the fact it is a humectant, meaning it is able to attract the water from the area surrounding the face and locking in that moisture into the skin.

This will keep your skin hydrated and looking full of bounce with fine lines and wrinkles notable reduced with a youthful looking complexion.

With the many skin benefits and the fact gluconolactone is so gentle you will find adding it into your skincare routine is very simple,

however, we must stress the importance of ensuring you first perform a patch test with any new product or ingredient that hasn’t been applied to your skin before.

If you have any further concerns about using gluconolactone then it is best to consult a doctor or trained professional.

How to use gluconolactone in your skincare routine

For some products, such as moisturisers the formulation is gentle enough to be applied twice a day.

This really depends on the particular product you decide to use when introducing gluconolactone in your daily skincare routine.

For more potent products, such as acid toners and peels it is best to limit how often you use them as it can cause irritation, especially if you have a sensitive skin type.

No matter which skin type you have, you may find your complexion will benefit from alternating products that contain complimentary ingredients that can be used safely with gluconolactone, such as hyaluronic acid and niacinamide.

For stronger ingredients such as retinoids and vitamin C that do not mix as easily with gluconolactone try applying them on different times of day, for example, vitamin C serum in the morning and a gluconolactone enriched serum in the evenings.

With this PHA being an humectant you will find that teaming hydrating products, such as serums, will boost the levels of moisture locked into the skin giving your complexion an all over more hydrated finish and luminous glow.

Dry patches will disappear and fine line and wrinkles will be ironed out with the skin gaining more bounce and any signs of skin sagging are lifted thanks to the hydration boost.

What are the side effects of gluconolactone?

Because gluconolactone is a PHA, there are very little, if any side effects to using it in your daily routine.

We must remember that it is still an acid and should be used with some caution, especially if your skin is sensitive or prone to eczema and dermatitis flare-ups.

When using an acid toner enriched in gluconolactone you can still expect to find your skin to appear red and flashed after application but should calm in a matter of minutes.

Dryness, stinging and itchiness should not occur and should you find you are suffering from these reactions it is advisable to stop using the product straight away.

I hope that today has given you a little insight into gluconolactone and the skin benefits you can expect to see when using it in your daily routine.

As we have previously discussed this clever PHA may not be a leading member of the formulation of your favourite skincare product,

however, it does play a vital part in taking your skincare to the next level of combating your skin concerns in rapid time.

If you are wanting to know more about PHAs in general, you can check out our blogpost about what polyhydroxy acids are and what are their skin benefits.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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