Glucosyl Hesperidin and Hesperidin In Skin Care

Glucosyl Hesperidin and Hesperidin are increasingly popular in anti-aging and skin lightening serums and creams. These powerful bioflavonoids offer numerous benefits for the skin. Known for their potent antioxidant and anti-inflammatory properties, they help reduce signs of aging, brighten skin, and improve overall complexion. Hesperidin benefits include enhancing microcirculation, reducing dark circles, and soothing irritated skin, making these ingredients essential for anyone seeking effective skincare solutions.

Polyphenolic compound that can become glucosyl hesperidin

Antioxidant, anti-inflammatory, and dark eye circle benefits

Safe and commonly used in skin care products

Glucosyl Hesperidin and Hesperidin

Glucosyl Hesperidin and Hesperidin are flavonoids known for their strong antioxidant effects, derived from citrus fruits. Flavonoids are a class of polyphenolic compounds that play a vital role in plant defense and human health, particularly in skin protection. These specific flavonoids are predominantly found in the peels and membranes of citrus fruits such as oranges, lemons, and grapefruits. Hesperidin, in particular, is a flavanone glycoside composed of the aglycone hesperetin and the disaccharide rutinose. When glucosylated to form Glucosyl Hesperidin, the compound becomes water-soluble, enhancing its absorption and effectiveness in skincare formulations. Their potent antioxidant properties help neutralize free radicals, protect against oxidative stress, and support overall skin health.

Hesperidin is a bioflavonoid predominantly found in citrus fruits. It has well-documented antioxidant, anti-inflammatory, and vasoprotective properties. Though traditionally studied for its systemic health benefits, this ingredient is increasingly used in skincare products due to its potential skin health benefits.

Glucosyl Hesperidin is a water-soluble derivative of hesperidin, a naturally occurring flavonoid found primarily in citrus fruits such as oranges and lemons. The glucosylation process enhances the solubility and stability of the original compound, making it more effective in cosmetic formulations.

Skin Care Products

What do they do in skin care?

Both forms of hesperidin are used in skincare for their potent antioxidant and anti-inflammatory properties. They help protect the skin from oxidative stress, reduce inflammation, and improve microcirculation, contributing to a more even skin tone and healthier complexion. They are often found in skin lightening products to treat dark spots, circles under the eyes, and hyperpigmentation.

Conditions

Hesperidin and glucosyl hesperidin are used in creams and serums to treat:

Dark circles under the eyes

Melasma

Hyperpigmentation

Post inflammatory hyperpigmentation

Tired eyes

Eye bags

Benefits

Glucosyl Hesperidin and Hesperidin are potent bioflavonoids derived from citrus fruits, widely used in skincare for their benefits when applied topically.

Antioxidant Properties: Scavenges free radicals and reduces oxidative stress in the skin.

Anti-inflammatory: Helps to calm irritated skin and reduce inflammation.

Vasoprotective Effects: Strengthens capillaries and improves microcirculation, which can reduce dark circles and under-eye puffiness.

Benefits specific to the Glucosyl variety-

Enhanced Absorption: The addition of glucose to hesperidin increases its solubility, enhancing its absorption and efficacy in the skin.

Safety

Both glucosyl hesperidin and hesperidin are considered safe for topical use. They are well-tolerated by most skin types, including sensitive skin. The EWG has not given a safety rating to these ingredients.

Research Studies

Reference 3 discusses several studies using this ingredient on skin. Here are some key findings discussed in this article:

Epidermal Permeability Barrier Function :

Topical applications of 2% hesperidin twice daily for six days significantly accelerated the recovery of the epidermal permeability barrier in young mice after acute disruption. This improvement was associated with increased proliferation, filaggrin expression, and lamellar body secretion.

In aged mice, the same treatment regimen over nine days not only accelerated barrier recovery but also reduced skin surface pH, enhanced differentiation, and increased lipid production and lamellar body formation.

In glucocorticoid-treated mice, topical hesperidin prevented abnormalities in barrier recovery and normalized skin surface pH and lipid processing.

UV Protection :

This ingredient showed protective effects against UVB radiation in keratinocytes. Pre-treatment with hesperidin reduced DNA damage, lipid peroxidation, and protein carbonylation, while also decreasing apoptotic index and reactive oxygen species.

Studies on dermal fibroblasts demonstrated that hesperidin inhibited matrix metalloproteinase expression, reduced β-galactosidase expression, and promoted collagen biosynthesis following UVA irradiation.

In mouse models, topical hesperidin reduced UVB-induced skin erythema, edema, lipid peroxidation, inflammation, and DNA damage. It also increased catalase and superoxide dismutase activity.

Anti-inflammatory and Antimicrobial Effects :

This ingredient’s anti-inflammatory properties help calm irritated skin by reducing the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Its antimicrobial activity has been demonstrated against various pathogens, contributing to its potential use in managing skin infections and promoting wound healing.

Anti-skin Cancer Properties :

This phenolic compound has shown potential in reducing the risk of skin cancer. Studies indicate that it can inhibit the proliferation of skin cancer cells and induce apoptosis, making it a promising agent for skin cancer prevention and treatment.

Skin Lightening :

Hesperidin inhibits melanogenesis, the process of melanin production, which helps in reducing hyperpigmentation and promoting an even skin tone. It works by inhibiting tyrosinase, a key enzyme in melanin synthesis.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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