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How to Safely Use Glycolic and Mandelic Acids Together
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How to Safely Use Glycolic and Mandelic Acids Together

25 June 2025


Can I Use Glycolic Acid and Mandelic Acid Together? A Complete Guide

If you’re exploring chemical exfoliants, it’s easy to feel like a skincare mad scientist. Mixing and matching acids can be confusing, especially when each one promises unique benefits.

Without a clear understanding, you might misuse them or cause irritation. Even if products say they are mild, they’re still acids that require careful handling and sun protection.

So, can you use glycolic acid and mandelic acid together? Let’s find out.

What Are Chemical Exfoliants?

Chemical exfoliants are acids that help remove dead skin cells from the surface of your skin. Unlike physical exfoliants, they dissolve the bonds holding dead skin cells together without scrubbing. This makes them effective, gentle, and suitable for many skin types when used correctly.

Two popular types of chemical exfoliants are alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs). AHAs, like glycolic and mandelic acid, are water-soluble and work mainly on the skin’s surface. BHAs, like salicylic acid, penetrate deeper into pores and are oil-soluble.

What Is Glycolic Acid?

Glycolic acid is a well-known AHA derived from sugar cane. It’s one of the most popular acids in skincare and found in many toners, serums, and moisturizers.

Glycolic acid has the smallest molecular size among AHAs.

Its small molecules allow it to penetrate deeply into the skin.

It works inside pores to clear excess sebum, dirt, bacteria, and impurities.

By exfoliating dead skin cells, it helps prevent blackheads, acne, and blemishes.

It also smooths fine lines and wrinkles, promoting a youthful, plump complexion.

Because glycolic acid removes dead skin cells, it increases skin absorption of other actives.

However, glycolic acid can be irritating for sensitive skin due to its deep penetration.

It’s generally best for skin types that are not overly dry or sensitive.

Once your skin builds tolerance, you can use glycolic acid up to twice daily.

It works well alone or combined with hydrating ingredients like hyaluronic acid.

What Is Mandelic Acid?

Mandelic acid is another AHA but less commonly discussed. It’s derived from bitter almonds and is used in both medical peels and over-the-counter skincare.

Mandelic acid molecules are larger than glycolic acid’s.

This means it penetrates more slowly and gently into the skin.

It’s considered one of the mildest AHAs, suitable for all skin types.

Mandelic acid exfoliates the skin’s surface, improving texture and tone.

It unclogs pores and reduces breakouts without irritation.

It’s especially effective at fading dark spots, hyperpigmentation, and acne scars.

Like glycolic acid, it helps your skin absorb other ingredients better.

Though gentle, it’s best to introduce mandelic acid gradually to avoid irritation.

Benefits of Glycolic Acid and Mandelic Acid

Both acids offer exfoliation and skin-renewal benefits, but they suit different needs:

Glycolic acid penetrates deeper, making it ideal for aging skin, uneven texture, and stubborn breakouts.

Mandelic acid works on the surface, great for sensitive skin and discoloration.

 

Both improve skin radiance, smoothness, and clarity.

They boost collagen production, helping to reduce fine lines.

Both can be layered with hydrating ingredients to keep skin balanced.

Can You Use Glycolic Acid and Mandelic Acid Together?

The short answer: yes, but not simultaneously.

Using both acids at the same time can overstimulate your skin, leading to:

Redness, Itching, Dryness, Flaking, Swelling

Increased sensitivity to sunlight

These effects result from over-exfoliation and can damage your skin barrier.

How to Use Both Acids Safely

Option 1: Alternate Days

Use glycolic acid one day, mandelic acid the next. This prevents irritation and allows your skin to recover between treatments. Many people prefer applying acids at night to avoid daytime UV exposure.

Option 2: Morning and Evening Split

Once your skin builds tolerance, you can use one acid in the morning and the other in the evening. Always follow with a broad-spectrum sunscreen of SPF 50 or higher to protect against UV damage.

Supporting Your Skin Barrier

When using exfoliating acids, hydration and protection are essential:

Use ingredients like hyaluronic acid to keep skin moisturized.

Niacinamide supports the skin barrier and reduces inflammation.

Avoid combining acids with harsh ingredients like retinoids or vitamin C initially.

Always apply sunscreen daily; acids make skin more prone to sun damage.

If irritation occurs, reduce frequency or pause acid use.

Is Mandelic Acid Stronger Than Glycolic Acid?

Technically, glycolic acid is stronger due to its smaller molecule size and deeper skin penetration.

Glycolic acid works deeper into the dermis.

Mandelic acid mainly affects the skin surface.

Mandelic acid is more gentle and better tolerated by sensitive skin.

The concentration of acid in a product also affects strength.

Look at ingredient lists: if an acid is near the top, it means a higher concentration.

A lower percentage of glycolic acid may be milder than a higher percentage of mandelic acid.

When to Avoid Using Glycolic or Mandelic Acid

Certain skin conditions or circumstances mean you should be cautious or avoid these acids:

Active eczema or dermatitis

Open wounds or sunburn

Very sensitive or reactive skin

During pregnancy, consult your healthcare provider

If you’re using strong prescription medications (retinoids, antibiotics)

Always do a patch test before adding new acids to your routine.

Signs Your Skin Loves These Acids

When used correctly, glycolic and mandelic acid can transform your skin:

Smoother texture and softer skin

Reduced breakouts and clearer pores

Brighter, more even skin tone

Fading dark spots and scars

Minimized fine lines and wrinkles

Better absorption of other skincare products

Frequently Asked Questions (FAQs)

Q: Can I mix glycolic acid and mandelic acid in the same product?

A: Usually no. Most products use one acid to avoid irritation. Layering two acids is not recommended without expert guidance.

Q: How long does it take to see results?

A: Typically, 4-6 weeks of consistent use show visible improvements.

Q: Can I use acids daily?

A: Start slowly, 2-3 times a week. Increase frequency as your skin builds tolerance.

Q: What should I do if I experience irritation?

A: Stop using the acids, moisturize, and consult a dermatologist if irritation persists.

Final Words

Glycolic acid and mandelic acid are powerful exfoliants that can elevate your skincare routine. Using them together is possible, but only with care.

Alternate their use or separate them by AM and PM routines to avoid irritation.

Support your skin barrier with hydrating and soothing ingredients and always protect yourself from the sun. With patience and consistency, these acids can give you smoother, brighter, and healthier skin.

If you want more personalized advice, reach out to us on Instagram or your trusted skincare professional. Happy exfoliating!

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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