Squalane and hyaluronic acid are two of the hottest ingredients in skincare right now. Both are showing up in a variety of products, from serums to face washes, moisturizers, and more.
Both are hydrating ingredients, but with different properties and functions. Depending on your needs, you may find that one or the other is a better fit for your routine.
To answer all of your burning questions about squalane and hyaluronic acid, we reached out to two dermatologists. Read on to learn what makes each ingredient unique, which one is best for you, and whether you can use them together.
What is squalane? Squalane is a lab-developed, hydrogenated form of squalene, which is “a naturally occurring lipid component of sebum that moisturizes the skin,” says Dr. Blair, FAAD, a board-certified cosmetic and medical dermatologist.
Blair Murphy-Ross, MD “Squalane is an emollient that softens the skin and helps retain moisture in the skin. [It] protects and supports the skin barrier and has antioxidant properties that can reverse and prevent free radical damage.”
If you’re wondering how squalane differs from squalene, Murphy-Ross explains that the former has the skincare benefits of squalene while making it more durable.
This makes squalane more suitable for use in skin care, as squalene is an unstable molecule. As we age, our natural squalene production decreases.
So if you find your skin is getting dry over time, these ingredients can help. “Squalane is also lighter than squalene, so unlike squalene, it’s better suited for acne-prone skin,” Murphy-Ross adds.
What is hyaluronic acid? Hyaluronic acid is a hydrating molecule that can attract and bind up to 1,000 times its weight in water.
“It’s a natural ingredient found in the skin, eyes, and joints that acts as a humectant, or a substance that draws water into the skin,” says Rebecca Marcus, board-certified dermatologist and founder of Maei MD.
Hyaluronic acid has an immediate plumping effect on the skin and can reduce the appearance of fine lines. That makes this hydrophilic ingredient very popular, and you’ll almost certainly see some brand indicate that their serum or moisturizer contains this powerful yet gentle acid.
Squalane vs. Hyaluronic Acid: The Difference Murphy-Ross tells us that the main difference between squalane and hyaluronic acid is their chemical makeup and the way they hydrate the skin. Here’s a little science lesson to explain:
“Squalane is a lipid and hyaluronic acid is a glycosaminoglycan (basically a chain of sugar molecules),” Marcus says. “Hyaluronic acid is a humectant, which draws water into the skin, while squalene is an emollient, which means it acts as a barrier, locking water into the skin.”
Just because they work differently doesn’t mean the two ingredients don’t have a lot in common. “Both help keep the skin healthy and hydrated,” Murphy-Rose says. “Both are hypoallergenic and often suitable for sensitive skin.”
“Both are humectant molecules that help increase the moisture content of the skin,” adds Marcus. “Both occur naturally in the body. Well, almost—squalene is naturally occurring, while squalane is a chemically modified form.”
Which squalane or hyaluronic acid is better for you is up to you. “Both are very effective ingredients that are suitable for all skin types, including sensitive skin,” says Murphy-Rose.
“Hyaluronic acid is great for moisturizing oily or acne-prone skin because it is lightweight and brings moisture to the surface of the skin without clogging pores. Squalane is a very effective ingredient for moisturizing dry skin, but
It can also be used in formulas that don’t aggravate acne.”
The frequency of use depends on the type of product, such as serum, lotion, or moisturizer. However, Murphy-Rose generally recommends using it once or twice a day. “Both work well in creams and lotions,” she says.
Can squalane and hyaluronic acid be used together? Yes, you can use squalane and hyaluronic acid together, whether you use separate products or try a formula that contains both. “If you’re using it alone, use hyaluronic acid first because it draws moisture into the skin,” Marcus advises.
“Adding squalane creates a barrier that holds moisture in the skin and prevents it from evaporating.” Ultimately, hyaluronic acid and squalane are great skincare ingredients that benefit most skin types. Because each ingredient helps restore the skin’s natural hydration process, both are great choices if you’re struggling with dryness or dehydration—just make sure you find a formula that works for your general skin type. “Both are great for dry skin, acne-prone skin, inflamed skin, and even sensitive skin,” Marcus says. “It really comes down to personal preference.”
