Progeline in Skin care: Trifluoroacetyl Tripeptide-2

Progeline, also known as Trifluoroacetyl Tripeptide-2, is a peptide frequently found in anti-aging serums such as SkinMedica TNS Advanced+ Serum. This innovative antiaging peptide works by inhibiting the production of progerin, a protein that accelerates cell aging. By reducing progerin synthesis, Progeline helps prevent skin sagging, making it a popular choice for those seeking to keep skin looking young. As a dermatologist in Miami specializing in researching the best skincare ingredients for the 16 different Baumann Skin Types, I am here to explain what this anti-aging peptide does for your skin and help you decide if it is a good addition to your skincare routine.

A peptide antiaging ingredient

Found in SkinMedica TNS Advance+ Serum

Blocks production of the protein progerin which is found in the aging disease progeria

Not many studies on skin have been done

What is Progeline: The Anti-Aging Peptide in Skin Care

Trifluoroacetyl Tripeptide-2, or Progeline, is an antiaging peptide found in anti-wrinkle serums such as SkinMedica TNS Advanced+ Serum. To find the best antiaging peptides and products for your skin type, take our quiz and look for products that display your skin type octagon to know they are right for your skin.

Progeline: Trifluoroacetyl Tripeptide-2

Trifluoroacetyl Tripeptide-2, is a cutting-edge peptide frequently included in advanced anti-aging skincare formulations. This three-amino-acid peptide seems to have the ability to inhibit the production of progerin, a protein that accelerates cellular aging. By reducing progerin synthesis, Progeline may help preserve skin elasticity, protect elastin, and prevent skin sagging. Its multifaceted benefits, including the reduction of wrinkles and the improvement of overall skin texture, have made it a popular choice in anti-aging products. As a dermatologist in Miami specializing in the best skincare ingredients for the 16 different Baumann Skin Types, I am here to explain what this anti-aging peptide does for your skin and help you decide if it is a suitable addition to your skincare regimen.

Products with Progeline

Trifluoroacetyl Tripeptide-2 is found in face and neck serums to prevent skin sagging. Here are some of my favorite products with progeline:

Benefits

This three-amino-acid peptide works by inhibiting the production of progerin, thereby reducing its detrimental effects on cellular structure and function. Manufacturers claim that Progeline can:

Preserve skin elasticity

Reduce sagging, particularly in areas such as the jawline

Diminish the appearance of wrinkles

Enhance overall skin texture and smoothness

Protect elastin, thereby helping to prevent sagging

Note that there is not much data to support these claims that I can find. If you find any good studies, please tell me in the comments.

I have seen this claim on the ingredient manufacturers website but cannot find any proof or publication to support the following:

“Clinical studies have shown promising results, with a 2% Progeline cream reportedly preserving skin elasticity and firmness by 20% in 28 days and lifting a sagging jawline by up to 10% in 56 days. Additionally, Progeline has been found to reduce progerin synthesis, inhibit matrix metalloproteinases (MMPs) and elastase, increase syndecan production, and contract collagen.”

Safety

According to the Environmental Working Group (EWG), Progeline, as Trifluoroacetyl Tripeptide-2, has a moderate safety profile with some concerns related to cancer, allergies, and developmental and reproductive toxicity. While it is generally considered safe for topical use, comprehensive safety data, particularly regarding long-term use and effects during pregnancy and breastfeeding, are limited.

There are no reports of allergic reactions, however, it is possible to have an allergic reaction to peptide ingredients.

The Cosmetic Ingredient Review (CIR) has not published any safety findings on Trifluoroacetyl Tripeptide-2, but the general consensus from other sources, such as the Cosmetics & Toiletries magazine and various ingredient databases, highlights that it is considered safe for topical use. Further research is necessary to fully understand its long-term effects

Side Effects

While Progeline is generally well-tolerated, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using any new skincare product if you commonly have skin allergies.

Pregnancy

The safety of Progeline during pregnancy and breastfeeding is not well-documented, so caution and consultation with a healthcare provider are advised.

Mechanism of Action

Progeline is an antiaging peptide that helps keep your skin looking young by blocking the production of a protein called progerin. Progerin makes cells age faster, leading to wrinkles and sagging skin. By stopping progerin from being made, Progeline helps maintain skin’s elasticity and firmness, keeping it smoother and less saggy.

What is Progerin?

Progerin is a defective variant of the lamin A protein, which is crucial for maintaining the structural integrity of the cell nucleus. In normal circumstances, lamin A undergoes a series of processing steps to become fully functional. However, in the case of progerin, a crucial processing step is skipped, resulting in a version of the protein that retains a hydrophobic oligoisoprene chain. This defective processing causes progerin to accumulate on the inner side of the nuclear envelope, disrupting its structure and function.

The accumulation of progerin is linked to the accelerated aging seen in Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder. In HGPS, a point mutation in the LMNA gene results in the production of progerin, leading to rapid aging and a significantly shortened lifespan. The structural distortions caused by progerin impair nuclear-cytoplasmic transport and increase cell death, contributing to the aging process.

Research suggests that progerin also plays a role in the natural aging process. The presence of progerin in individuals without progeria indicates that it may contribute to the gradual decline in cellular function and vitality as we age. Strategies to prevent progerin accumulation or enhance its clearance are being explored as potential anti-aging therapies.

Sun and Progerin

Sun exposure, particularly longwave ultraviolet A (UVA) radiation, has been shown to increase levels of progerin in the skin, accelerating the aging process. UVA radiation penetrates deeper into the skin compared to UVB, reaching the dermis and causing oxidative damage. This damage leads to alternative splicing of the LMNA gene, resulting in increased production of progerin. A study by Takeuchi and Rünger (2013) demonstrated that UVA exposure, but not UVB, induces progerin expression and causes HGPS-like nuclear abnormalities in skin cells

Conclusion

In conclusion, Progeline (Trifluoroacetyl Tripeptide-2) shows promise as an anti-aging ingredient by targeting progerin, a protein linked to accelerated aging. While initial studies and product claims are encouraging, further research is needed to fully understand its benefits and safety profile. As with any skincare ingredient, it is important to consider individual skin type and sensitivity when incorporating Progeline into a skincare routine.

DQH Knowledge drop: In your 20s, your skin cell turnover decreases. (Cell turnover is a key component in keeping your skin youthful.) You know what else slows down? Your collagen production. Starting in your 20s, collagen decreases by about 1 percent per year. Should you want to prevent fine lines and wrinkles, start by eliminating behaviors that contribute to premature aging. “If it’s bad for you, it’s bad for your skin,” says dermatologist Michel Somenek. “Cigarette smoking reduces blood flow to the skin and causes premature wrinkling and a dull skin texture. Making the repeated pursed motion to inhale can also cause smoker’s lines. Alcohol and recreational drugs are toxins for the skin that damage its cellular structure and DNA,” Somenek tells us. “The faster you eliminate vices while you are young, the better chance your skin and body have to recuperate.” Also, adopting an anti-aging routine in your 20s is key. After all, the best offense is a good defense. We spoke to Somenek and experts Joshua Ross and Audrey Kunin to find out more. Keep reading for the best anti-aging products for your 20s, according to skincare professionals. Sunscreen “We all know that the sun is the number one cause of skin aging and starting the prevention in your 20s is very important,” Ross says. “The majority of your sun damage won’t start to appear until you’re in your 30s, so don’t wait until you see it surface or you’ll be behind the curve. Stay ahead of it with a good-quality zinc-based sunscreen worn daily.” Farmacy Green Defense Daily Mineral Sunscreen An invisible sunscreen with SPF 30, plus botanical extracts meant to protect skin with tons of antioxidants. Bonus: It’s clean and fine to use under makeup. Bareminerals Complexion Rescue™ Tinted Moisturizer Broad Spectrum SPF 30 Although we recommend you use your SPF and moisturizer separately, we also understand moments when you don’t have time or energy for that extra step. For those times, this bareMinerals moisturizer is a great thing to have on hand. Vitamin C Serum “A great introduction to anti-aging is to start with a vitamin C serum in your morning skincare routine,” Ross says. “It’s a powerful antioxidant that will neutralize free radicals and brighten the skin.” He adds that it’s a great way to counteract the effects of the sun’s harmful rays, which, as previously mentioned, are among the biggest causes of premature aging. Drunk Elephant C-Firma™ Vitamin C Day Serum The Drunk Elephant C-Firma is a lightweight serum that promises to give skin a glow by combining the brightening powers of vitamin C with ferulic acid, l-ascorbic acid, and vitamin E. The included sodium hyaluronate is meant to replace hydration loss, so you shouldn’t have to deal with any irritation. Sunday Riley C.E.O. Rapid Flash Brightening Serum This potent serum is jam-packed with vitamin C (15 percent, to be exact), which means it’s a potential superstar at both brightening skin and dousing it in antioxidants. Peptides Using peptides on your skin has many benefits, says Somenek. “The skin barrier is what defends the body against pollution, UV rays, bacteria, and toxins. It can be damaged by several everyday factors. Using topical peptides aids in building a stronger barrier,” he says. “Peptides comprise elastic fibers, which are a type of protein. These fibers help to make skin appear taut and firm. Peptides can also help repair damaged skin, relieve inflammation, and even out skin tone. Some peptides can kill acne-causing bacteria that is common in 20-somethings.” Kunin agrees, saying, “Peptides are an excellent entry point for supporting collagen.” She recommends looking for face and eye treatments that contain these collagen-boosting powerhouses. Charlotte Tilbury Magic Eye Rescue Cream This Charlotte Tilbury super-emollient eye cream has a base of coconut oil and shea butter (read: it’s incredibly hydrating). Botanicals plus peptides are meant to help reduce dark circles and boost collagen, respectively. This creamy moisturizer serves up potent collagen-boosting peptides and pycnogenol, and antioxidant-rich vitamin C. “Instead of sitting on top of the skin, peptides penetrate the outer layer so they go deep. The ‘signals’ they send tell the cells to produce elastin and collagen, which are needed for youthful-looking skin,” explains Somenek. At-Home Peel Pads Remember that skin cell turnover fiasco we talked about earlier? One way to help support it is by exfoliating. “Exfoliation is important to help keep skin fresh and luminous,” Kunin says. She recommends using at-home peel pads as an easy and effective way to exfoliate. “The goal in your 20s is to fight the slowing pace of cell turnover. It is wise to use products that gently exfoliate, yet still remove oil and other impurities. Products that have Alpha Hydroxy Acids (AHA) or Beta Hydroxy Acids (BHA) are a good choice.” According to Somenek, you should only exfoliate two to three times a week. “People of all ages are guilty of over-exfoliating and that can be too much of a good thing,” he says. Dermadoctor Kakadu C Intensive Vitamin C Peel Pad A few swipes of this Derma Doctor powerful peel pad promise to leave your skin glowing and smooth, thanks to the seven (yes, seven) types of chemical exfoliants, including AHA and BHA. It also contains vitamin C via Kakadu plum extract for added brightening and antioxidant protection. KEY INGREDIENTS Kakadu plum extract is sourced from the Kakadu plum, a fruit grown in northern Australia. It contains vitamin C, which restores the skin’s natural barrier, increases collagen production, and soothes irritation. Dr. Dennis Gross Skincare Alpha Beta® Universal Daily Peel Pads These are the gold standard of peel pads, with a cult following and over 900 five-star reviews on Sephora. They’re easy to use and contain a blend of anti-aging exfoliating acids. Emollient Night Cream “In your 20s, you need to start upping the hydration in your skincare routine. You may have been cautious of over-moisturizing because of acne in your teens, but as you enter your 20s, your skin transitions and becomes drier,” Ross says. “I recommend an emollient night cream added into your evening skincare regimen.” “Twenty-somethings need to make sure that they are not using creams that will clog their pores and cause excess oil production,” says Somenek. Opt for non-comedogenic products. Cerave Skin Renewing Night Cream One great choice is the CeraVe Skin Renewing Night Cream, which is a non-comedogenic night cream that leaves skin soft and glowy. It combines the moisturizing powers of ceramides and hyaluronic acid. RoC Retinol Correxion Max Hydration Creme “The best night cream ingredients contain retinol, benzoyl peroxide, and/or salicylic acid or hyaluronic acid. The goal is to moisturize, yet remove excess oil,” says Somenek. This Roc Retinol Correxion cream fits the bill as it contains both hyaluronic acid and retinol so it promises to moisturize while also being non-comedogenic.

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