SkinMedica Products and Company History

Wondering where to buy SkinMedica products online? We are an authorized dealer and we run ecommerce for over 280 doctors that sell SkinMedica. We can help you shop by your skin type to find products from one of the best selling medical-grade skincare brand – SkinMedica®? As a dermatologist and skin care expert, I understand the importance of using products that are effective, evidence- based and recommended by dermatologists. I will help you find the best SkinMedica products online.

SkinMedica is a top skincare brand that was founded by a dermatologist, recommended and sold by many dermatologists, and has gained recognition for its groundbreaking use of growth factors in skincare. SkinMedica products were the first to contain growth factors in an antiaging skin serum.

I will help you find the best SkinMedica products for your skin type! Then I will discuss the technology known as TNS, how it was developed, and the history of SkinMedica. Don’t miss the SkinMedica company history section at the end of this blog- it is fascinating!

Ready to shop for SkinMedica products?

Step one is to take the quiz to find out your skin type. After the quiz you will receive a custom skincare routine where you can combine SkinMedica products with other skincare brands in your routine.

SkinMedica Products

In my Miami dermatology practice, I like to pick the best skincare products from SkinMedica and combine them with other brands in a custom skincare routine that matches my patient’s skin type. These are the products that I tend to recommend the most and a brief description of why I like them. Click the individual product to see a complete dermatologist review on that SkinMedica product. (These are being added so not all products have these yet.)

The Best SkinMedica Product

The very best SkinMedica product combines the TNS technology with the TNS-MR technology. You can read more about these different technologies and how they were developed below. The SkinMedica TNS Advanced + Serum is the most advanced and best growth factor serum with TNS (tissue nutrient solution).

SkinMedica TNS Advanced + Serum

I’m impressed by SkinMedica’s TNS Advanced+ Serum—it has 450 growth factors derived from fibroblasts and stem cells, more than previous TNS serums. These growth factors boost collagen and cell activity to truly address aging skin. The lightweight, non-comedogenic serum works well for all wrinkle-prone skin types. My patients see improvements in wrinkle, tone and texture on the face, neck and chest using TNS Advanced+ Serum. It can be layered before retinol in your skincare routine to boost it’s antiaging abilities.

This serum has Lactococcus Ferment Lysate and Saccharide Isomerate to stabilize the skin’s microbiome .It also contains the antiaging peptide Dimer Tripeptide-43.

Click to learn more about this bestselling antiaging serum!

Shop for SkinMedica Products

SkinMedica is most known for their serums. They have good antiaging, skin lightening, and hydrating serums. Take the skin type quiz to see which SkinMedica Products are best for you. In this section I will give you the same advice that I give me patients on how to choose a SkinMedica serum to use in your skincare routine.

Best Antiaging Serums from SkinMedica

SkinMedica has several types of antiaging serums with different combinations of these antiaging ingredients:

Growth factors

Tissue Nutrient Solution

Retinol

Vitamin C

Hyaluronic acid

You can click on the ingredient above to learn about it or continue reading to get advice on how to choose which SkinMedica antiaging serum is best for you.

SkinMedica Retinol

Retinol is always the first antiaging serum you should buy. It is the most effective and has the most evidence-based research. The SkinMedica retinol serum is well made, has a good form of retinol, and is manufactured and bottled in a light and air free environment that helps keep retinol stable and effective.

These are some of the best dermatologist-recommended retinols. They come in 3 strengths. Retinol beginners should always choose the lowest strength and follow these how to use retinol instructions. Do not use retinol if your skin is stinging, peeling, or you have active rosacea.

This is the lowest strength retinol that SkinMedica makes. If you are beginning a retinol, choose this strength and use it every third night after your moisturizer in your evening skincare routine.

Once you are used to the 0.25% retinol and are using it every night, you should increase to the mid strength 0.5% retinol. This strength is not as strong as prescription tretinoin. Follow our retinol instructions on how to increase the strength from 0.25% to 0.5%.

The 1% retinol is the strongest retinol by SkinMedica. It is not as strong as the weakest prescription strength tretinoin (0.025%), but it is very effective and can cause side effects if you do not use it properly in your skincare routine. Make sure you are using it with the right cleansers and moisturizers for your Baumann Skin Type to avoid irritation.

SkinMedica TNS and Growth Factors

Many SkinMedica products have growth factors and it can be hard to choose. This guide can help you figure out which growth factor serum to buy if for some reason you do not want to take the free skin type quiz which will also tell you which SkinMedica product is right for your skin type.

This is the most advanced of any growth factor TNS serum on the market. If you cannot tolerate retinol, this is the best antiaging serum for you. You can use this in your morning or night regimen. You can use it before retinol a night. This is a good choice if you have reactive sensitive skin such as rosacea and cannot use a retinol. Do not use if you have had skin cancers on your face.

SkinMedica HA5

The SkinMedica HA5 serum contains five distinct molecular weights of hyaluronic acid (HA) ranging from 800 kDa to less than 10 kDa. This allows the product to provide both surface hydration as well as deeper skin penetration and hydration. The 800 kDa HA is an extremely long chain molecule that creates a moisture-binding film on the skin’s surface, acting as a humectant. The longer chain 500 kDa and 200 kDa HA molecules also provide humectant properties while being small enough to penetrate into the epidermis. The 50 kDa medium chains and less than 10 kDa short chains are able to penetrate through the epidermis into the dermis. These tiny HA fragments bind water and help the serum carry other ingredients, like vitamins and antioxidants, deeper into the skin where they can provide more targeted treatment.

In addition to the multi-weight HA, the HA5 also contains several peptides including Tripeptide-29 and Tripeptide-1. These peptides boost collagen and elastin production in the dermis, helping to firm and smooth skin texture.

Overall, the combination of different sized HA molecules, collagen-supporting peptides, antioxidants and other ingredients allows the HA5 to deeply hydrate while also treating signs of aging for a more youthful appearance

This hyaluronic acid serum also has antioxidants like green tea leaf extract and vitamin E to provide protection against free radical damage.

This serum is great light moisturizer for oily skin types. Dry skin types should use this HA serum in combination with a barrier repair moisturizer.

The Best Skin Lightening Products from SkinMedica

The best serum from SkinMedica to lighten dark spots is SkinMedica Lytera 2.0. This was the first topical serum on the market to contain tranexamic acid.This is one of the most popular serums to treat dark spots because it blocks melanin production in many different ways.

SkinMedica Lytera 2.0

SkinMedica Lytera 2.0 has these skin lightening ingredients that work together to treat hyperpigmentation:

Niacinamide- PAR-2 Blocker

Phenylethyl Resorcinol- Tyrosinase inhibitor

Tranexamic Acid

Artemisia Capillaris Flower Extract

Vibrio Alginolyticus Ferment Filtrate

Alteromonas Ferment Extract

Tocopheryl Acetate(Vitamin E)-Antioxidant

Phytic Acid- alpha hydroxyacid- exfoliant

the story behind skin medica

The Story Behind SkinMedica

SkinMedica’s journey as a bestselling skincare brand began when the interest in injectable dermal fillers grew to the point that research was looking into how to make dermal fillers from human collagen instead of cow collagen. The process of growing human tissue in the lab developed into the discovery of Tissue Nutrient Solution (TNS) and the birth of one the top 10 bestselling skincare brands in the world.

TNS Recovery Complex was the first growth factor serum released on the market in 2001.

Dr. Gail Naughton

Scientist Gail Naughton and her team first described using fibroblast cell culture media for topical use around 1999. They named this growth factor rich serum NouriCel . (3,4)At this time injectable collagen (Zyderm® and Zyplast®) were new cosmetic procedures and fillers known as CosmoDerm® and CosmoPlast® were being developed from fibroblasts grown from a piece of foreskin using technology developed by Dr. Naughton. The rumor was that the donated skin was from a circumcision of someone in the company’s son but I have no idea if this is true. CosmoDerm® and CosmoPlast® were approved by FDA as dermal fillers in March 2003. The fibroblast cells used to make CosmoDerm and CosmoPlast grew in a conditioned media that was full of growth factors produced by the growing fibroblasts. This media was called Nouricel® and later Nouricel-MD® but now is known as Tissue Nutrient Solution® (TNS).

“I began hearing about growth factors for skin rejuvenation in 2001 when I was writing Cosmetic Dermatology: Principles and Practice (McGraw Hill 2002).” Leslie Baumann MD

I was a Professor at the University of Miami running the Department of Cosmetic Dermatology when Dr.Richard Fitzpatrick began lecturing on the use of growth factors to rejuvenate the skin. I was doing research trials for the company Inamed® who made the CosmoDerm® and CosmoPlast® fillers from which TNS was extracted. I remember being very excited about this new technology. It was so new that growth factors were only briefly mentioned in my textbook on cosmetic dermatology which was the first cosmetic dermatology textbook in the world. That’s how new growth factors were at the time! But we all knew they would play an important role in skin rejuvenation and restoring skin collagen.

This is an image from 2003 of the large vats used to grow fibroblasts to make the dermal fillers CosmoDerm and CosmPlast. The media used to make TNS was isolated from these cells. The technology has changed and been improved since this time with the acquisition of HIstogen’s technology.

Dr. Richard Fitzpatrick

Dr.Richard Fitzpatrick founded SkinMedica in 1999. He started talking about growth factors in skin care around 2000-2001. (Note that this is Richard Fitzpatrick who is not the same Dr.Thomas Fitzpatrick from Harvard Medical School who wrote the textbook and described the Fitzpatrick Skin Types.)

I am not sure how Gail Naughton and Richard Fitzpatrick teamed up, but they both lived in San Diego California at the time. SkinMedica launched the first growth factor serum using TNS in 2001.

Tissue Nutrient Solution

This groundbreaking discovery of growth factors in cultured fibroblast media paved the way for the development of TNS (Tissue Nutrient Solution), a proprietary blend of growth factors, soluble collagen, antioxidants, and matrix proteins. This growth factor-rich media is a key ingredient in SkinMedica products. Over the years, SkinMedica has continually improved the formulation, ensuring that it remains at the forefront of medical-grade skincare. In 2017, SkinMedica (owned by Allergan at the time) acquired the skincare line Regenica owned by Dr. Naughtons’s company Histogen. (7) Regenica used Multipotent Resignaling Complex (MRCx) which also contains growth factors. There is a new version of TNS called TNS-MR that combines the TNS and MRCx technologies to form the most advanced growth factor serum on the market now. TNS Essential Serum contains 380 dermal derived growth factors while TNS-MR contains 450 epidermal and dermal derived growth factors.

“Histogen has developed a next-generation regenerative cell technology, harnessing the power of growth factors and stem-cell signaling molecules for skin rejuvenation that complements Allergan’s flagship growth factor technology—TNS,” said Rahul Mehta, PhD, vice president of research and development at SkinMedica, an Allergan Company.” MedEsthetics July 27, 2017

Human Fibroblast Conditioned Media

Human Fibroblast Conditioned Media is the INCI name found on the product ingredient label and is essentially the same thing as Tissue Nutrient Solution (TNS) or Multipotent Resignaling Complex (MRCx). It is the name for the solution that contains growth factors.

Allergan and SkinMedica

SkinMedica Is owned by Allergan: Allergan is owned by the pharmaceutical company Abbvie. Allergan acquired SkinMedica in 2012 for approximately $350 million. It is not one of the top science-based medically proven skincare brands in the world.

Is SkinMedica the Best Skincare Brand?

The best skincare brand for you depends upon which of the 16 Baumann Skin Types you are, your values, and budget.

Take the free skin type quiz to find out which products are best for you and build a custom skin care routine.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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