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Squalane and Hyaluronic Acid: Two Hydration Heroes, One Perfect Routine
Beauty

Squalane and Hyaluronic Acid: Two Hydration Heroes, One Perfect Routine

28 April 2025


Squalane vs. Hyaluronic Acid: Which One is Better for Your Skin?




In the vast world of skincare, squalane and hyaluronic acid have both risen to prominence as two of the most sought-after ingredients. From serums to moisturizers, face washes, and even eye creams, these two ingredients are hailed as miracle workers when it comes to hydrating the skin. But despite their widespread use, they have distinct characteristics that can make one more suitable than the other depending on your skin’s needs. So, how do you decide which one is better for your skin? Let’s break down the differences, benefits, and optimal ways to incorporate them into your skincare routine.



What is Squalane?




Squalane is a hydrogenated version of squalene, a naturally occurring lipid found in our skin’s sebum. This substance is vital for maintaining healthy skin because it plays a key role in hydration, providing the skin with necessary moisture. However, while squalene itself is incredibly beneficial, it has one major drawback: it is an unstable molecule. That’s where squalane comes in.



Squalane is a more stable, synthetic version of squalene that has been processed for cosmetic use, making it much more durable in skincare formulations. This transformation allows squalane to retain the beneficial properties of squalene while being less prone to oxidation. The stability of squalane makes it an excellent choice for skincare products.




Blair Murphy-Rose, MD, FAAD, a board-certified dermatologist, explains that squalane acts as an emollient, meaning it softens and smoothes the skin’s texture while sealing moisture in. It also helps protect the skin’s barrier and has antioxidant properties that shield the skin from free radical damage, which is often caused by environmental stressors like pollution, UV rays, and harsh weather conditions.



Squalane is particularly helpful for individuals experiencing dry skin, as it mimics the body’s natural oils and replenishes lost moisture. It’s also non-comedogenic, meaning it won’t clog pores, making it safe to use even for people with acne-prone skin. Additionally, squalane is lightweight compared to other oils, making it an excellent option for those looking for hydration without feeling heavy or greasy on the skin.




What is Hyaluronic Acid?



Hyaluronic acid is a naturally occurring substance in the body, primarily found in the skin, eyes, and joints. Its main role is to act as a humectant, a substance that draws moisture from the environment and helps the skin retain it. Hyaluronic acid has the remarkable ability to hold up to 1,000 times its weight in water, making it one of the most hydrating ingredients in skincare.




According to Dr. Rebecca Marcus, a board-certified dermatologist and founder of Maei MD, hyaluronic acid has an immediate plumping effect on the skin. By attracting moisture and binding it to the skin, hyaluronic acid helps reduce the appearance of fine lines and wrinkles, giving the skin a smoother, firmer appearance. As a result, it has become a staple ingredient in hydrating serums, moisturizers, and eye creams.



Hyaluronic acid is particularly known for its ability to hydrate oily and acne-prone skin. Since it doesn’t clog pores and doesn’t add any heavy oils to the skin, it’s a great option for individuals with oily or combination skin types who are looking for a lightweight, non-greasy way to stay hydrated.




Squalane vs. Hyaluronic Acid: The Key Differences



While both squalane and hyaluronic acid offer incredible benefits to the skin, they work in different ways. Let’s explore these differences in detail:




Chemical Composition:



The most significant difference between the two ingredients is their chemical structure. Squalane is a lipid, a fat-based molecule, while hyaluronic acid is a glycosaminoglycan, which is a long chain of sugar molecules. These differences influence how the two ingredients interact with the skin.




Mode of Hydration:



Hyaluronic acid is a humectant, meaning it draws moisture into the skin from the environment. It’s excellent for giving the skin an instant boost of hydration. However, because it pulls moisture from the air, it requires an occlusive agent to lock that moisture in. That’s where squalane comes into play.




Squalane, on the other hand, acts as an emollient, meaning it forms a barrier on the skin to prevent moisture loss. It helps to seal in hydration and protect the skin’s natural moisture.



Skin Types:




Both ingredients are suitable for most skin types, including sensitive skin. However, there are certain skin types that might benefit more from one over the other.



Hyaluronic Acid: Ideal for oily and acne-prone skin because it hydrates without clogging pores or causing breakouts.




Squalane: Best for dry skin because it helps replenish moisture and supports the skin’s barrier function.



Application Frequency:




Both squalane and hyaluronic acid can be used daily. However, since squalane provides a barrier against moisture loss, it’s often used as a final step in a skincare routine (especially in the evening), while hyaluronic acid is often applied earlier in the routine to draw moisture into the skin.



Can Squalane and Hyaluronic Acid Be Used Together?




Yes! In fact, using squalane and hyaluronic acid together can be extremely effective. Since they work in different ways, combining them ensures that your skin gets both an immediate boost of hydration (from hyaluronic acid) and long-lasting moisture retention (from squalane).



Here’s how to use them together:




Layering Order: When using both ingredients, start by applying hyaluronic acid first. Since it’s a humectant, it draws moisture into the skin, which is why it should go on first when the skin is still slightly damp.



Follow with Squalane: After applying hyaluronic acid, follow up with squalane to lock in all the moisture and keep your skin hydrated for hours.




Whether you choose to use two separate products or a single serum that contains both ingredients, layering them in the right order can provide maximum hydration benefits. Additionally, many products on the market are now formulated with both hyaluronic acid and squalane to take advantage of their complementary properties.



Which One Is Better for Your Skin?




The decision to use squalane or hyaluronic acid depends on your skin’s needs:



If you’re dealing with dry skin, squalane might be more beneficial because it will help replenish lost moisture and prevent further dehydration.




If you need instant hydration and are looking to reduce fine lines and plump up the skin, hyaluronic acid is a great option.



If you have sensitive or acne-prone skin, both ingredients are suitable, but you might prefer hyaluronic acid if you’re looking for something light and non-comedogenic.




In most cases, however, combining both ingredients into your routine can give you the best of both worlds: deep hydration and long-lasting moisture retention.


Conclusion: Hydration Heroes for Every Skin Type

Squalane and hyaluronic acid are both incredible skincare ingredients that can hydrate, nourish, and protect your skin. Whether you have dry, oily, sensitive, or combination skin, both ingredients have unique benefits that cater to a wide range of skincare needs.

Ultimately, the choice between the two depends on your individual skin concerns and preferences. If you’re looking for a lightweight, non-greasy moisturizer, hyaluronic acid may be the answer. If you want something more nourishing and protective, squalane might be more suited to your needs.

By understanding how these ingredients work and how they can be incorporated into your routine, you can better address your skin’s hydration needs and achieve a smoother, more radiant complexion. Both ingredients are highly effective on their own but can work even better when used together in the right order for ultimate hydration and protection.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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