Stem Cells vs Growth Factors vs Exosomes In Skin Care

This is a guide that explains the difference between human stem cells vs growth factors vs exosomes in face serums.

There are many antiaging ingredients, and it can get confusing and hard to decide which are the best for you to use on your face.

It would be a shame for you to buy an expensive antiaging serum and then waste your money by use it incorrectly or using it in the wrong step of the skincare routine.

And guess what?

Most stem cell or growth factor skin care products are not worth the money!

I am a skin care expert and I can guide you to find the best antiaging products with stem cells, growth factors or exosomes for your skin type.

Take the free quiz and get a personalized custom skin care routine. We will tell you exactly what step to use stemcells, growth factors and exosomes in your skin care routine and what other products to layer them with.

All you need to do is take the skin care routine quiz and hop by your Baumann Skin Type.®

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Stem cells vs growth factors vs exosomes in antiaging skin care

Human Stem Cells in Serums

Problems with Stem Cells in Skin Care Products

Human Growth Factors in Serums

Problems with Growth Factors in Skin Care

Exosomes

Why exosomes are better than stem cells and growth factors

References

Stem cells vs growth factors vs exosomes in antiaging skin care

This can be hard if you do not understand the science. This blog explains the difference between stem cells, growth factors and exosomes.

Note that this article only discusses human growth factors. Growth factors and stem cells from plants such as apples are a complete waste of money. We are not apples, our skin is completely different than apple skin, and we do not need the same growth factors they do. So just forget about apple stem cells and do not waste money buying them. They are not worth it.

Exosomes made by stem cells

Human Stem Cells in Serums

There are different layers of skin. Each skin layer has different types of cells and therefore different types of stem cells.

The human derived stem cells that are found in skincare products are stem cells from:

Keratinocytes in the epidermis

Fibroblast from the dermis

The hair follicle

Body Fat

Umbilical chords

Placenta

The function of the stem cell and the signals, growth factors, and exosomes they give off is determined by which layer and cell type they come from.

We will focus on stem cells in the dermis because these are more important in antiaging skin care products because they make:

Collagen

Elastin

Hyaluronic acid

Glycosaminoglycans

Other important cell components

In the skin’s dermis, stem cells turn into mature fibroblasts. Lots of research has shown us that stem cells, when placed in wounds in in cell cultures, change the way the cells around them act. They do this by releasing exosomes and growth factors like TGF-beta. (Exosomes also contain growth factors).

This is why stem cells have been used in antiaging skin care and wound therapy for many years. It is undisputable that they have dramatic effects and naturally occurring stem cells in the skin are important to have young skin.

However, there are problems with stem cells in skin care products.

Problems with Stem Cells in Skin Care Products

There are many reasons that stem cells in skin care are not good. This first is that when they are plant derived stem cells such as apple stem cells, they do not carry the correct cell signals that human skin needs to increase collagen production and block the causes of aging such as cellular senescence.

Here are more reasons that stem cells do not work:

Human stem cells must come from fat, bone marrow, placenta, skin biopsies, cell cultures and other biologic material.

This is expensive

FDA is changing requirements for use

May not be safe- it depends on the source

Stem cells do not live in the skin product bottles and jars. They die quickly

Topically applied stem cells cannot get down into the dermal layer of the skin to perform their functions

For these reasons, stem cells in topical antiaging skin creams are worthless and not worth the money.

Human Growth Factors in Serums

Growth factors are secreted by many cell types, including stem cells. They are signaling molecules used in cell-to-cell communication. Once growth factors are excreted by cells, they then must move through the extracellular matrix between cells to get to the target cell. Once at the target cell, growth factors bind a receptor on the target cell so the target cell can “hear” the signals of the growth factor.

Each type of growth factor has a different message, target receptor, and action that is causes. For example, some growth factors cause more blood vessels to form, while others stimulate cells to make more collagen. Growth factors work best in groups, with each playing its role. The best growth factor to get skin to increase collagen production is TGF-beta.

There are many types of growth factors in human skin. Find a list of growth factors used in skin care here.

Problems with Growth Factors in Skin Care

Many growth factor serums are either not worth the money, don’t work, or have safety issues.

The problem with growth factors in skin care products are:

Growth factors may not be safe such as EGF.

They may not remain active in a skin cream that has sat on the shelf for months

They get broken down before they reach the target tissue

You need the right combination of growth factors to cause the desired results

We often do not know which growth factors are actually in the skin care products

Old skin cells cannot “hear” them. (Heparan sulfate helps this problem)

Exosomes

Exosomes are protective spheres known as extracellular vesicles that contain many signaling molecules including growth factors. They are little spherical capsules surrounded by a bilayer membrane. Their function is to hold signaling molecules in a safe environment and deliver them directly to the target cell.

New data has shown that the beneficial effects of stem cells actually occur because of the exosomes that stem cells secrete. In fact, applying the exosomes instead of stem cells has the same effect! So new science has shown us that it is the exosome containing the growth factors that is important, not the stem cell.

In this video I discuss exosomes and skin aging with a Regenerative Medicine Dermatologist and a Transplant Cardiologist who have done a lot of research on the rejuvenation effects of exosomes. They developed the exosome skin care line known as Plated Skin Care.

Exosomes are better than stem cells and growth factors in antiaging skin care

Exosomes are secreted from stem cells, They carry growth factors, RNA and other cell signals. Exosomes protect the growth factors and carry them directly to the target cells.

Exosomes carry important molecules such as:

mRNA

micro RNA

growth factors

immune signals

So the answer is exosomes are better than growth factor and stem cells serums. Exosomes contain growth factors and are what is in stem cells that gives stem cells skin rejuvenation properties.

The best exosomes are derived from platelets and umbilical chords because these carry the cell signals needed for wound healing and production of structural cellular components like collagen and glycosaminoglycans.

But the real question is- do you need an exosome serum? Or should you be using a different antiaging ingredient such as retinoids?

Well- it depends upon your Baumann Skin Type.

Don’t guess on what skin care serums to buy. Let us help you shop for antiaging skin care products using your Baumann Skin Type.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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