The 9 Best Growth Factor Serums Tested and Rated in 2023

I’ve been a loyal user of retinol serums and creams for years, but when I turned 32 in June, I felt like I needed to step up my anti-aging routine a bit and try different products and ingredients.

After weeks of research and consulting with dermatologists, I discovered growth factor face serums. Many experts told me that growth factors are one of the most important ingredients for smoothing, plumping, and toning skin because they stimulate collagen and elastin production and signal skin cells to repair and regenerate themselves. Of course, I had to experience all of these benefits for myself, so over the course of four months

tested over 20 different growth factor serums, weighed their pros and cons, and created this top list. Here’s a sneak peek: Keep reading for a full list of the best growth factor serums and important info you need to know

What you need to know when choosing a growth factor serum, according to dermatologist Heather Rogers, MD, and plastic surgeon Dr. Catherine Chang.

1. PCA SKIN Pro-Max Age Renewal Advanced Anti-Aging Serum with Micro-Growth Factor Technology After testing this growth factor serum for a month, I’m excited.

Normally, I wouldn’t see any changes to my skin after such a short trial, but I noticed that my forehead wrinkles looked smoother and the skin around my mouth and lower cheeks looked firmer. By using this serum, I can go longer between Botox injections, which I really like.

2. Bioeffect EGF Eye Serum: I’ve recently noticed some fine lines and crow’s feet around my eyes. My dermatologist recommended that I use a retinol eye cream to smooth it out, but while I can usually tolerate retinol

not so well around my eyes.

That’s where the Growth Factor Eye Serum comes in handy. It helps to visibly plump and smooth the wrinkles around my eyes without causing dryness or flaking—in fact, I think it also helped reduce my stubborn dark circles.

3. SkinMedica TNS Advanced+ Serum: Even if you don’t know much about growth factors, you’ve probably heard of this legendary serum. SkinMedica’s TNS Advanced+ serum is a favorite among dermatologists, estheticians, and beauty editors.

It’s a blend of growth factors, peptides, green microalgae, and marine extracts that tones, firms, and smooths skin with continued use. Just watch these before-and-after videos for proof.

4. Glo Skin Beauty BioRenew EGF Drops: Glo Skin Beauty has some of my favorite tinted moisturizers (I highly recommend the C-Shield Anti-Pollution Hydrating Tint SPF 30). When I saw they also make an epidermal growth factor (EGF) serum, I knew I had to try it.

The formula is designed to be a boosting serum, so you can easily add a few drops to your favorite moisturizer, face primer, or face foundation. Ingredient-wise, the combination of vegan growth factors (they mimic proteins found in human skin cells), hyaluronic acid, and peptides is the perfect trio for firming and plumping skin.

Dr. 5 Diamond’s Metacine InstaFacial Plasma: I first tried this growth factor serum when I met Dr. Diamond’s signature InstaFacial (which, by the way, counts celebrities like Kourtney Kardashian, Hilary Duff, and Olivia Culpo as fans).

I immediately fell in love with its lightweight texture and the way the formula absorbed into my skin without leaving a greasy residue. The result? I was impressed with how smooth and firm my skin felt, and also found that my pores looked tighter and less noticeable.

6. Neocutis Bio Serum Firming and Hydrating Anti-Aging Serum: Neocutis’ Bio Serum is an absolute anti-aging powerhouse. Yes, it’s pricey, but the formula is packed with all the good stuff, including growth factors and peptides to smooth wrinkles and tighten sagging skin, acetylglucosamine to gently exfoliate and brighten, and hydrating, moisture-replenishing hyaluronic acid. It has a thicker texture than the other serums on this list, so if you have combination or oily skin, you can easily use it as a moisturizer.

7. Biopelle Tensage Growth Factor Boost Serum 40 Ampoules Post-Op: I tested these growth factor ampoules after a clear, glowing laser treatment, and they sped up my recovery time, leaving my skin soft and smooth,

literally a miracle.

As recommended by my doctor, I used one bottle daily for 10 days after treatment to let the growth factors, hyaluronic acid, and antioxidants combine to repair my skin and enhance the renewal and regeneration effects of the laser.

In fact, I love the serum in these little bottles so much that I use it when I travel, or for a week or two when my skin feels like it needs a reboot.

8. Allies of Skin Peptide and GF Advanced Lifting Serum: I’m addicted to nearly every Allies of Skin product I’ve tried, including this firming and lifting serum. The bottle contains a cocktail of growth factors that repair and

strengthen the skin, tighten sagging skin, and smooth fine lines. Unlike other anti-aging serums I’ve tested that take weeks (and sometimes months) to work, I noticed my skin looked smoother and less dull within days of using it twice a day. Very important.

9. ZO Skin Health Growth Factor Serum: Several dermatologists and aestheticians have recommended this growth factor serum from ZO to me over the years and say that their patients and clients always get compliments on their skin when they incorporate it into their daily skincare routines.

It leaves your skin visibly brighter, plumper, and reduces signs of aging, including fine lines, rough texture, and uneven skin tone. The gel-like formula also has a velvety texture and absorbs well into the skin.

Do growth factors really work for the skin?

Black lines If your goal is to achieve smoother, firmer, and more toned skin, growth factors really work. “Growth factors stimulate fibroblasts, the cells responsible for collagen production, improving skin structure and firmness, and reducing fine lines and wrinkles,” says Dr. Rogers. Growth factors can also improve the skin’s wound healing process and help repair damaged skin. Some growth factors can even help soothe the skin by shutting down inflammatory pathways, improving skin barrier function, and reducing redness, adds Rogers. Dr. Chang says it usually takes six to eight weeks for the skin to show the above changes with regular use. So remember that patience is the key to success when adding a growth factor serum to your routine. Are Growth Factors Better Than Retinol? Black lines No, growth factors are not better than retinol at treating the signs of aging. “I tell my patients that a growth factor serum is the sixth skin-care product they should buy,” says Dr. Rogers. “Cleanser, facial moisturizer, sunscreen, antioxidant serum during the day, and AHA or retinol serum at night are must-haves, followed by a growth factor serum,” says Dr. Rogers. Retinol is one of the most researched ingredients in skincare, and its ability to stimulate collagen and elastin production and promote cell turnover has been proven time and time again.

No, a growth factor serum won’t necessarily replace a retinol serum or cream, but it is a great product to use in combination or overnight. What is the best growth factor serum for face? Black Line Best Growth Factor Serums

Tailored specifically for your skin type and skin concerns. If you have sensitive skin, you should make sure the growth factor serum you choose is free of potential skin irritants, such as fragrances and dyes. If your skin

If you have oily skin or are prone to acne, it is recommended to choose a growth factor serum that is labeled oil-free and/or non-comedogenic. If you have dry or dehydrated skin, consider a growth factor serum with moisturizing ingredients such as hyaluronic acid

or glycerin is the best choice.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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