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The Right Way to Layer Hyaluronic Acid and Tretinoin for Clear, Hydrated Skin
Skin Care

The Right Way to Layer Hyaluronic Acid and Tretinoin for Clear, Hydrated Skin

9 May 2025



Should I use Hyaluronic Acid Before or After Tretinoin?

When it comes to skincare ingredient combinations, one of the most effective is retinol and hyaluronic acid. This is because both are able to deliver impressive skin results whilst working together to reduce the risk of retinol causing excessive dryness to the skin and allowing hyaluronic acid to keep the skin plumped and hydrated throughout the day.

Now you’re probably wondering why I’m talking about retinol when the title of this blog post mentions tretinoin, well believe it or not tretinoin is a name for the drug Retin-A and the active ingredient retinol. I know, it all sounds very technical, but not to worry as things will make a lot more sense once we have figured out whether you should use hyaluronic acid before or after tretinoin.

What does tretinoin do for your skin?

Tretinoin is used for treating acne, breakouts as well as other skin concerns such as signs of ageing, hyperpigmentation and loss of elasticity. Due to the fact it is an extremely potent ingredient you will often find it is obtained through prescription. Tretinoin works on the skin the same ways as retinol so needs to be introduced into your daily routine correctly. This is because skin experiences some dryness and flaking which is a common result when you first apply retinol to the skin. Once it has built its tolerance you’ll find the dryness subsides and you begin to see results. You can find out more about tretinoin and how it benefits the skin over on our blog.

Is there a difference between Retin-A and tretinoin?

Not really, it may feel confusing, but retin-A is the brand name for the drug tretinoin, yes just like the Beckham family have a brand name. It just happens that retin-A, or retinol is the name the ingredient is mainly called and recognised by. They are both a potent form of vitamin A which when used on the skin can combat all manner of skin concerns, from acne to fine lines. As I have already mentioned it is vital you use any form of retinol correctly and introduce it slowly into your routine. Start off by using it once a week and slowly make your way up to 3 times a week. If you are wanting to find out more, check out our blog post about retinol and its skincare benefits.

Can I use hyaluronic acid serum with Retin-A?

Absolutely! If anything, I would strongly suggest teaming these two powerhouse ingredients together. This will not only help keep your skin’s protective barrier remain fully functioning, with the correct levels of water enabling it to combat damage caused by daily exposure to free radicals, such as pollution, UV rays and other environmental skin stresses. When teaming these ingredients together you’ll find retin-a can work deep in the lower layers of the skin, reversing signs of ageing and problematic breakouts without the worry of the skin becoming too uncomfortable and dry thanks to the clever humectant properties of hyaluronic acid locking moisture into the skin.

Should I use hyaluronic acid before or after tretinoin?

Not really, many favour applying tretinoin before hyaluronic acid to ensure any dryness is avoided. However, when it comes to applying skincare, it is considered important to remember to follow the basic rule, and that is to apply products from thinnest to thickest. This will obviously have an effect on whether you apply hyaluronic acid before or after tretinoin. If I could however make the suggestion of applying hyaluronic acid before the potent tretinoin you will find your skin remains comfortable and happy. You’ll also find that because the layers of the skin are fully hydrated, they act more like a wet sponge absorbing any other product that are applied to the skin allowing them to penetrate into the lower layers of the skin.

How do you layer retinol and hyaluronic acid together?

As I have already mentioned layering skincare ingredients comes down to their consistency, remember, thinnest to thickest. The easiest way to remember the steps is serum, followed by oils and finally moisturisers. By applying skincare formulas this way you will find they are able to work on the skin and not battle against the physical barrier caused by the thicker consistencies. If you’re not wanting to follow my suggestion in the previous part, then the best way of layering retinol and hyaluronic acid is to first apply retinol to dry skin followed by a serum packed with hyaluronic acid. This will keep the skin hydrated and combat any potential dryness and flaking that as mentioned, is a common side effect when you first add retinol to your skincare routine.

Which is better hyaluronic acid or retinol?

Both of these ingredients carry a huge amount of reputation and popularity, they are both adored by beauty experts and enthusiasts alike. With this in mind, I’m tempted to say you’d be missing a trick if you don’t use both of these powerhouse ingredients in your daily routine.

Whilst retinol contains a huge amount of skin benefits that help to reduce the appearance of fine lines and wrinkles, as well as improving the appearance of skin texture, evens out skin tone and combating acne and breakouts. With retinol there is the slight downside to the short-term dryness it can cause to the skin, but as I have mentioned it does not last long and if used correctly will result in you having the best complexion.

As for hyaluronic acid, this humectant is hugely beneficial for the skin to remain hydrated and moisturised leaving the skin looking plumped and youthful. This is important to remember as quite often dehydration can not only lead to the skin looking older with visibly more fine lines on the surface, but with the protective barrier being notably weakened will lead to the skin becoming damaged from free radical exposure.

It really boils down to you and which concerns you have with your skin, however, seeing as though you are able to use both of these effective ingredients together, then why not reap the rewards and give your skin the best routine leaving it at its healthiest, happiest state.

If you have any questions about this topic, or anything else skincare related come and join us over on Instagram for more expert advice, giveaways and exclusive product launches.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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