The Role of TGF-β in Effective Anti-Aging Skin Care

Transforming Growth Factor Beta (TGF-β) in Skin Serums

Transforming growth factor beta, commonly known as TGF-β or TGF-β, is an important growth factor in anti-aging serums.

TGF-β in the skin promotes collagen production and is therefore added to many anti-aging serums. However, growth factors in skin care products may be unstable and unable to penetrate the skin.

(1) Is TGF-β serum worth buying? Maybe, maybe not.

There are many anti-aging skin care serums on the market that contain anti-aging ingredients. How do you know which one is the best?

The only scientifically sound way to find the growth factor or anti-aging serum that is best for you is to study your Bowman skin type.

What is TGF-β?

TGF-β is the most important growth factor that regulates the production of extracellular matrix (ECM) proteins (such as collagen and elastin) and glycosaminoglycans (such as hyaluronic acid and heparin sulfate) in the skin.

There are different types of TGF-beta.

TGF-β1 is found in skin care products for skin regeneration, anti-aging treatments, and wound healing. (2)

TGF-β in the Skin

Transforming growth factor beta (TGF-β) is a multifunctional cytokine in the transforming growth factor family.

These proteins play a vital role in regulating various cellular processes including cell proliferation, differentiation, migration, and apoptosis.

In mammals, the TGF-β family consists of several isoforms such as TGF-β1, TGF-β2, and TGF-β3. These are synthesized as precursor proteins and then activated through a complex maturation process.

TGF-β is a potent regulator of many aspects of immune function, wound healing, and tissue regeneration, playing a key role in the development of various tissues and homeostasis.

Effects of Natural TGF-β on Skin

In terms of skin health, TGF-beta plays a vital role in maintaining skin integrity and healing.

It promotes the synthesis of extracellular matrix components such as collagen, elastin, and fibronectin, which are essential for the firmness and elasticity of the skin.

During wound healing, TGF-β is essential for regulating inflammation and recruiting cells to the site of injury, where it supports tissue repair and scar formation.

In addition, it helps regulate the balance of skin cell proliferation and differentiation, thereby maintaining the normal structure and function of the skin.

Dysregulated TGF-β signaling has been linked to a variety of skin disorders, including scarring, fibrosis, and certain inflammatory diseases.

How TGF-β Promotes Skin Collagen Production

Transforming growth factor beta (TGF-β) is a superstar in skin collagen production.

This powerful protein regulates cell growth, proliferation, and differentiation, making it an important player in wound healing and skin regeneration.

When TGF-β binds to receptors on dermal fibroblasts, it triggers a signaling cascade that ultimately stimulates collagen synthesis.

Studies have shown that TGF-β stimulates fibroblasts to produce more type I and type III collagen, the two main structural collagens that make up more than 90% of the dermal matrix.

TGF-beta also inhibits collagen degradation by blocking matrix metalloproteinases.

Additionally, TGF-beta attracts immune cells (i.e. macrophages) to the wound site, where they release more TGF-beta, further boosting collagen formation.

This cytokine can even stimulate fibroblasts to transform into active myofibroblasts, which synthesize abundant collagen as part of the skin repair process.

TGF-beta – Benefits for Skin

TGF-beta has many benefits for the skin, as it activates processes in the skin that make it stronger and younger. It influences many of the processes associated with skin aging.

Therefore, a good TGF-beta product can improve fine lines and skin texture.

This anti-aging growth factor:

Stimulates dermal collagen remodeling, increasing collagen production (1),

Increases hyaluronic acid production (4) and

Decreases matrix metalloproteinases (5), enzymes that break down these important skin components.

How does TGF-beta work?

When the TGF-beta receptor is activated, the TGF-beta/Smad signaling pathway is activated. This important signaling pathway helps the skin rejuvenate.

Do TGF-β serums really work?

TGF-β is applied topically to the skin in the form of serums, creams, or lotions and is designed to be absorbed by the skin.

The TGF-β molecule itself is relatively large and has difficulty penetrating the outermost layer of the skin (the stratum corneum).

To increase its penetration, it is often encapsulated in liposomes or other carrier systems, allowing it to reach deeper layers of the skin and work.

The effectiveness of topical TGF-β skin products may vary depending on the formulation and individual skin type.

Research has not been completed on the effectiveness of topical TGF-β, but some studies suggest that it may have positive effects on the appearance of the skin.

These include reducing wrinkles and improving skin texture and tone, presumably by stimulating collagen production and other skin renewal processes. However, not all formulations are effective.

Skin Care Products with TGF-β

The best brand for TGF-β in skin care is Plated SkinScience. Their revolutionary use of cutting-edge anti-aging technology makes them one of the best brands on the market today!

These are my favorite Plated SkinScience products:

How does TGF-β relate to skin aging?

UV radiation inhibits the TGF-β/Smad signaling pathway, a process known as extrinsic skin aging.

Blocking the TGF-β/Smad signaling pathway can lead to photoaging, skin wrinkling, and the development of skin cancer. (6)

How can I increase levels of TGF-β in my skin?

In addition to using TGF-β in skin serums, there are other ways to stimulate fibroblasts to release more TGF-β.

17β-estradiol increases TGF-β production (7).

Topical application of retinoids increases the activity of the TGF-β/Smad signaling pathway. (8).

Fibroblasts exposed to hypoxia produce more TGF-β. (9).

This is another reason why I prefer retinoids to treat skin wrinkles.

Is TGF-β safe for skin application?

TGF-β appears to be safe when applied to the skin. Indeed, a reduction in TGF-β may make the skin more susceptible to cancer, but more data are needed. (10,11)

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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