Thiamidol in Skin Care

What is Thiamidol?

Thiamidol (Isobutylamido thiazolyl resorcinol) is an up and coming skin lightening ingredient with potent tyrosinase inhibiting properties.

It is considered to be as powerful or more than hydroquinone, and as of today, no safety concerns have been identified.

This skin lightening ingredient has been making waves in the industry, though it is currently understudied and patented by a single brand.

This ingredient is synthetic, it is not derived directly from any plants or animals. It is made in a lab.

So far, all indications are positive that thiamidol is a safe, effective tyrosinase inhibitor for most skin types.

To find out if this ingredient would fit well in your custom skin care regimen, take our quiz and find your Baumann Skin Type!

How Does Thiamidol Work?

Thiamidol is a Tyrosinase Inhibitor.

This ingredient is very new, so there is no definitive answer on how exactly it interacts with the skin long term. That being said, we can still take note of what the compound is made of.

In our diagram above, notice the hexagon segment on the left of the structure with two legs labeled “HO” and “OH.” That structure is a resorcinol. Resorcinol is a very common tyrosinase inhibitor.

There are two other main components of the structure: the pentagon shaped structure is called a thiazole. Thiazoles are a family of compounds that demonstrate antimicrobial and anti-inflammatory properties. (6,7)

The structure to the right of that is called an amide and since it has 4 non-linear carbons it is isobutylamide.

“Amides” can be understood as a category of compounds that are required for the formation of proteins. Amides play a role in binding and forming amino acids, which are important for developing collagen, repairing the skin barrier, and more. (5)

It is important to note that even though all of these compounds are present in thiamidol, current research has only tested its efficacy as a skin lightener. There is not significant evidence to suggest that this ingredient is a notable anti-inflammatory, moisturizing, or antimicrobial compound.

benefits of thiamidol

Benefits of Thiamidol

Current research suggests that Thiamidol might be a very good skin lightening ingredient. Studies have found it more effective than hydroquinone on some patients.(3)

As a tyrosinase inhibitor, thiamidol is able to help prevent hyperpigmentation before it begins.

Tyrosinase inhibitors stop the conversion of tyrosine into melanin, which is the pigment that gives skin its color.

Some studies claim that Thiamidol is effective at preventing UVB induced changes in pigmentation. (4) This could support its use in some sunscreens.

To find out if Thiamidol is right for your skin care routine, get your recommended regimen through our quiz and see if you need a skin lightener.

Thiamidol side-effects

Side-effects

Some patients in research and the consumer market have experienced mild contact dermatitis from thiamidol.

Otherwise, current studies have not found any notable side-effects associated with thiamidol use.

However, because it is a potent skin lightener, it could be expected that applying this ingredient on spots it isn’t needed can result in some slight skin bleaching.

Is Thiamidol Safe?

As of this blog, no comprehensive safety analyses on thiamidol have been conducted by either the Cosmetic Ingredient Review Panel (CIR) or the Environmental Working Group (EWG), or by any major independent organization.

That being said, some small studies have found general tolerance and safety to thiamidol. (3,9)

If you are concerned about safety, it frankly might be worth waiting for more research before choosing products with thiamidol even though there are currently no contraindications for its use.

Thiamidol for skin lightening

Thiamidol for Skin Lightening

Thiamidol is a potent tyrosinase inhibitor which has successfully undergone studies for PIH, post-acne hyperpigmentation, and Melasma treatments. (3,8)

Thiamidol is increasing in popularity because it has so much potential as a skin lightener. In addition, studies have found that thiamidol is effective for protecting the skin from UVB radiation based pigment changes. (4)

Because no significant stinging or irritation is commonly associated with thiamidol, it can be a great choice for sensitive skin types who need a tyrosinase inhibitor.

PIH, (Post inflammatory hyperpigmentation), has also been shown to improve in Thiamidol trials. (3,8)

Thiamidol for Melasma

Thiamidol is extremely promising as an ingredient in melasma treatment products.

Studies have found that Thiamidol can be just as effective as many of the most popular tyrosinase inhibitors, such as hydroquinone in treating melasma. (8,9)

If you have melasma, thiamidol could be a good ingredient for you depending on your skin type.

Thiamidol vs hydroquinone

Thiamidol Vs Hydroquinone

Thiamidol is exciting because it might be the replacement for hydroquinone that cosmetics companies have been waiting for. Thiamidol is just as, if not more potent than hydroquinone at inhibiting tyrosinase.

At the same time, it has demonstrated far fewer causes for safety concerns. Thiamidol does not seem to absorb into the body as much as hydroquinone, and has not indicated carcinogenesis.(3)

Overall, thiamidol could be seen as the newer, better, safer version of hydroquinone. Whether it has any additional characteristics has yet to be observed in research. As more research comes out on this fascinating ingredient, we will be sure to update this blog so you have nothing but the most up-to-date information on skin health.

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DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.

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