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Vitamin C in Skincare: What to Pair and What to Skip
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Vitamin C in Skincare: What to Pair and What to Skip

30 May 2025


What Should Not Be Taken With Vitamin C?

You’ve probably heard of vitamin C and know exactly why it should be part of your skincare routine. However, there’s a lot of confusion about what shouldn’t be combined with vitamin C.

Stay tuned to learn more, and follow us on Instagram if you have any questions. What Should Not Be Taken With Vitamin C?

Vitamin C is notoriously unstable and has an acidic pH, making it difficult to combine with other powerful skincare ingredients.

Here are three of the most important ingredients to avoid when using vitamin C:

Vitamin C and retinol. Retinol is one of the most potent ingredients in skincare, with powerful anti-aging properties and a variety of benefits:

It boosts collagen production while speeding up skin cell turnover.

Many people with different skin types find this dosage too high, so you should go slow when using retinol in your daily routine to avoid causing severe irritation.

If you combine any form of retinol with vitamin C, it could be too irritating for your skin, regardless of your tolerance for retinol.

To avoid this, you should include vitamin C in your evening routine. This protects the skin from UV rays and other damage caused by free radicals.

Retinol works best at night because its effectiveness decreases when exposed to the sun.

Vitamin C and Niacinamide?

Niacinamide, also known as vitamin B3, is found in many different skin care products. Due to its moisturizing properties, it moisturizes the complexion and regulates the skin’s sebum production.

This unique benefit ensures that Niacinamide keeps the skin plump and reduces all signs of blemishes and acne.

The problem with Niacinamide and Vitamin C is that they both have similar benefits for the skin. When used together, they cancel each other out and render both ineffective.

If you plan to use both products daily, wait at least 10 minutes between applications, or use every other day for best results. Vitamin C and AHA/BHA

Avoid taking Vitamin C and AHA/BHA (such as glycolic acid and salicylic acid) at the same time.

Since these acids cause chemical exfoliation, combining them with Vitamin C can over-irritate the skin, causing severe irritation, reactions, and extreme dryness.

Also, keep in mind that all of these ingredients have a low pH level and can cause a serious imbalance that can completely ineffective your skincare routine. What can you combine vitamin C with?

Thanks to the powerful antioxidant effects of vitamin C, your skin will be rejuvenated, repaired, and your complexion will be brighter.

At the same time, the signs of free radical damage will be visibly reduced.

While vitamin C alone can produce impressive results, there are ingredients that work effectively with this powerful substance.

The best combination of ingredients with vitamin C, vitamin E, ferulic acid, vitamin B, and hyaluronic acid.

To keep your skin healthy and happy, I recommend consulting a doctor or dermatologist to find the best combination without worrying about side effects.

Can vitamin C and niacinamide be mixed?

No, it is not recommended to mix vitamin C and niacinamide, as the two ingredients will cancel each other out and therefore be completely useless.

As mentioned above, you can use niacinamide and vitamin C in your daily skincare routine. Leave at least 10 to 15 minutes between each application.

Another way to use these two ingredients is to alternate the times or even days of use.

If you want to learn more about using Niacinamide and Vitamin C, check out our dedicated blog post on Beauty Insider. Can Vitamin C be used with Hyaluronic Acid?

Yes, you can! Your skin will thank you. Vitamin C can cause mild irritation and redness, especially for those with dry and sensitive skin.

With hydrating ingredients like Hyaluronic Acid, you can combat dryness and irritation by increasing moisture.

The result is a plump, radiant complexion that is pampered and protected from free radical damage, and looks refreshed.

Does Vitamin C undermine Retinol?

The short answer is yes. The more precise answer depends largely on the pH of the different formulations of products containing Vitamin C and Retinol.

You need to consider the effectiveness of both ingredients. A high-strength version may cause gastrointestinal upset.

Due to the low pH of both ingredients, mixing or applying multiple layers may cause an adverse reaction, resulting in dry skin, irritation, redness, and itching.

To avoid these issues and adverse side effects, I recommend applying a vitamin C serum at the end of your morning skincare routine, followed by a day product with an SPF of 30 or higher.

At night, you can use a retinol-rich product.

Which comes first, vitamin C or hyaluronic acid?

If you use vitamin C and hyaluronic acid in different products, I recommend starting with the vitamin C. Serums with vitamin C have thinner, lighter formulas than hyaluronic acid.

The rule of thumb for skin care is: start with the thinnest and end with the thickest.

Adding a hyaluronic acid-rich serum to a vitamin C product will strengthen the skin barrier and retain moisture on the surface of the skin. This keeps the skin plump, hydrated, and healthy.

Does vitamin C clog pores?

Yes, it can, but only if you use an unstable form of vitamin C, as ascorbic acid (another name for vitamin C) oxidizes when exposed to light and air.

This can lead to the formation of blackheads, which are more serious for skin conditions. To avoid this, make sure you use the best form of vitamin C.

If you have any concerns, discontinue use of this product and consult your doctor or dermatologist.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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