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Which Vitamin C Serum is Best?
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Which Vitamin C Serum is Best?

24 February 2025


Which Vitamin C Serum is Best?




I am a dermatologist in Miami who tests skin care products like ascorbic acid serums to see which Vitamin C serums work best for your skin type. We test these serums on the 16 different Baumann Skin Types. In my 20 years of skin care research, I have found which Vitamin C serums work well for different ages, skin types, genders, and skin concerns. In this blog I will help you find a Vitamin C serum to treat your skin type and your skin concerns,



The best Vitamin C Serums are expensive – so you want to make sure you choose the right one. This blog will talk about when to splurge on Vitamin C and when to save. I will tell you which affordable Vitamin C serums are good. Whether you are in your 20s, 30s, 40s, 50s or 60+, Vitamin C might be right for you. I will discuss which Vitamin C serums to use to treat different skin issues such as wrinkles and hyperpigmentation. If you have acne, rosacea, melasma, dry skin, oily skin, or sensitive skin, this can affect which Vitamin C serum you should use. This blog also talks about the different types of Vitamin C ingredients that are in skincare products and the benefits and downsides of each type.




The easiest way to find a good Vitamin C serum that is right for you is to take the quiz and shop by your Baumann Skin Type. I used my research to develop software that helps you build the perfect skincare routine for your skin type. Take the quiz to see if Vitamin C should be in your skincare routine – and to see which is best for your skin type.



Best Vitamin C Serums




There are liquid Vitamin C products, serums, gels, lotions and creams. Serums are the most popular form of ascorbic acid used in skincare routines. Vitamin C in cosmetics such as facial foundations and powders is not effective. We suggest sticking with a serum or liquid formulation. Vitamin C is hydrophilic so it works well in aqueous solutions.



These Vitamin C serums work for most Baumann Skin Types:




Alastin C-Radical Defense Antioxidant Serum – has the most antioxidants



Cera Ve Skin Renewing Vitamin C Serum – most affordable




Derma Made Antioxidant C Serum + – the best of the cheap Vitamin C serums



La Roche Posay Vitamin C Serum – uses similar technology to SkinCeuticals but more affordable




Skinceuticals CE Ferulic – the bestselling Vitamin C serum in the world.



Skinceuticals Serum 10 AOX – very good and affordable but must be used in 4 weeks after opening.




There are so many good Vitamin C serums and even more bad Vitamin C serums. Keep reading to learn more about how to choose a Vitamin C serum.



Top dermatologist-recommended Vitamin C Serums




There are many types of Vitamin C skincare products, but Skinceuticals was the first Vitamin C Serum and is still the most popular and top selling. Most dermatologists recommend Skinceuticals C E Ferulic- but there are many good Vitamin C serums on the market. Lets see how these Vitamin C serums compare.



SkinCeuticals CE Ferulic is the best-selling Vitamin C serum. It is very stable due to the addition of ferulic acid and Vitamin E and has ascorbic acid in the correct pH to be effective. It has been the best selling of all the ascorbic acid serums for many years. However, if you have oily skin, it may feel heavy, tacky and sticky. Best for dry skin types. If you have oily skin, you may choose to use this instead of a moisturizer.




Skinceuticals Vitamin C Serums


The reason Skinceuticals has different types of Vitamin C is because there are different skin types and you should match your Vitamin C Serum to your budget, skin concerns, and other products that you will layer Vitamin C with in your skincare routine. Keep reading to see which is best for your skin type.

How do you know if Vitamin C is right for your skin type? Take our skin type quiz!

Diagnose your Baumann Skin Type

Receive our step by step routine recommendations

Choose from a list of Vitamin C serums right for you

Read reviews from others with your same Baumann Skin Type

After you take the quiz, look for your Baumann Skin Type octagon that corresponds with your Skin Type. This allows you to shop by your skin type.

Take the Quiz

Some Baumann Skin Types need Vitamin C Serums

Vitamin C Serums By Skin Type

Our skin type quiz divides you into 16 Baumann Skin Types and 4 sensitive skin subtypes. When you take the quiz, we will tell you which products are right for you and help you build a skincare routine. I have also divided up my Vitamin C serum recommendations by skin type below.

Vitamin C for Dry Skin Types

If you have a dry skin type then SkinCeuticals CE Ferulic is suitable for you. It contains 15% pure vitamin C, vitamin E and ferulic acid in a moisturizing gel that sometimes feels greasy but most dry skin types love. Lotions and creams may have Vitamin C in them, but the serums are usually more potent.

These Vitamin C Serums are also good for dry skin types at risk for aging or an uneven skin tone:

Vitamin C for Oily Skin Types

For oily skin types, we recommend ascorbic acid serums rather than creams or lotions. Oily skin types usually do not like Skinceuticals CE Ferulic because it feels sticky on oil skin. For this reason I prefer these Vitamin C serums from Skinceuticals for Oily skin types. I also like these other brands of Vitamin C for oily skin types.

Vitamin C for Sensitive Skin Types

There are 4 types of sensitive skin and Vitamin C is not right for all of them. In fact, most sensitive skin types with acne, rosacea, skin stigning, and allergies do not do well with Vitamin C.

Take the quiz before buying ANY Vitamin C serums to see if they are right for your type of sensitive skin. Below is the advice I give my sensitive skin patients about Vitamin C.

Take the Quiz

Rosacea-Prone Skin and Vitamin C

Rosacea skin types are a type of sensitive skin that do not do well with Vitamin C. The low pH of Vitamin C causes stinging that will irritate rosacea prone skin. When I recommend Vitamin C to my rosacea patients, I choose one that has soothing ingredients and a form of Vitamin C that does not have to be a low pH to work.

Revision C+ Correcting Complex is mild enough for sensitive skin types, rosacea-prone skin, and even skin that stings. It contains Vitamin C in the form of tetrahexyldecyl ascorbate. This Vitamin C serum is unique in that it supports the microbiome. The diglucosyl gallic acid has soothing effects.

I often use Jan Marini C-ESTA serum in my rosacea-prone patients. It has ascorbyl palmitate which is a form of Vitamin C that does not sting. It is lipid soluble and is more hydrating than other Vitamin C serums. For very dry skin types with rosacea, this also comes in a cream form.

Acne-prone skin and Vitamin C

In some cases, Vitamin C can make acne worse. It is unknown why this is.However, if you If you have acne-prone skin and pimples cause dark spots on the skin, Vitamin C can help lighten post acne hyperpigmentation.

Acne is a form of inflammation that can stimulate the production of melanin, but using a vitamin C serum can both decrease inflammation and prevent the dark spots that pimples can leave behind. Darker skin types are more prone to getting dark spots on the skin after an acne pimple has cleared.

Our favorite Skinceuticals Vitamin C Serum for acne is SkinCeuticals C + AHA,.

This vitamin C serum that combines the power of alpha-hydroxy acids to exfoliate the skin and keep it clear of blemishes and clogged pores.

This serum contains 15% pure vitamin C (l-ascorbic acid) and a 10% combination of glycolic and lactic acids, which help to break the bonds on the outer layer of the skin, thus breaking up the excess pigmentation.

Not all Baumann Skin Types can tolerate AHA so make sure you take the quiz and see if this product is right for you.

Affordable Vitamin C Serum

Skinceuticals Vitamin C Serums do not go on sale very often so you want to make sure you know which ones you want to buy when the price goes down.

Skinceuticals Serum 10 AOX+ is the most affordable Skinceuticals Vitamin C serum and it works well.

Here are prices of other Vitamin C Serums for comparison:

The bestselling Vitamin C Serum is SkinCeuticals C E Ferulic and is priced around $182.

Our favorite affordable Vitamin C is Skinceuticals Serum 10 AOX+ which is around $76,

The least expensive good Vitamin C is CeraVe Skin Renewing Vitamin C Serum which costs around $27.

These cheap Vitamin C Serums we do not recommend for various reasons such as packaging, quality, type or amount of ascorbic acid:

L’Oreal Paris Revitalift Vitamin C Face Serum at Amazon is priced around $18.

Yes To Grapefruit Brightening Serum at Amazon is priced at $13.

Sephora Collection Super Glow Serum with Vitamin C+E at Sephora is priced around $20.

TruSkin Vitamin C Facial Serum at Amazon is priced at $22.

If you want to save money of Vitamin C make sure you choose one that works. Avoid these worthless prodcuts:

Vitamin C in jars

Vitamin C serums not stored in temperature controlled rooms (We have an air conditioned warehouse and quick turnover of our inventory)

Vitamin C serums left in the sun or heat such as in your car.

Expired Vitamin C

Vitamin C’s not packaged properly

Vitamin C exposure to air during the packaging process

Basically- if it’s really cheap- you need to be skeptical. Feel free to email us or visit us on social media to ask what affordable Vitamin C serums are best.

Best Vitamin C Serum for over 50

If you are 50+, you need more than just Vitamin C in your skincare routine. Take our quiz to build a routine. Most people in their 50s need retinoids, growth factors, and exosomes in addition to ascorbic acid. This is because older skin cells (fibroblasts)do not hear cell signals well, do not make cell signals as well as they did when they were younger, and need help making energy to produce collagen. One reason is there are more senescent cells in older skin.

So if you are over 50, look for Vitamin C serums that combine ingredients like niacinamide, ascorbic acid, retinoids, heparan sulfate, exosomes and growth factors.

Alastin C-Radical Defense Antioxidant Serum is great for skin that is 50 years and older. It is good for men and women. Even post menopausal women will benefit.. It has 15 antioxidants which is more than any other Vitamin C serum! The are:

1. Sodium Ascorbate (Vitamin C) – Neutralizes free radicals and supports collagen production.

2. Coenzyme Q10 (Ubiquinone) – Boosts cell regeneration and defends against oxidative damage.

3. Green Tea Extract (Camellia Sinensis) – Fights inflammation and scavenges harmful ROS.

4. Physalis Angulata – Contains physalins that neutralize free radicals

5. Lactoferrin – Reduces oxidative damage by controlling iron buildup.

6. Ergothioneine – Protects skin cells from oxidative stress and promotes cellular repair.

7. Carnosine – Shields skin from glycation, a process that accelerates aging.

8. Ectoin – Protects the skin from environmental stressors like UV and pollution.

9. Centella Asiatica – Enhances wound healing and reduces inflammation.

10. Ginger Root Extract (Zingiber Officinale) – Calms irritation and protects from pollution.

11. Olive Leaf Extract (Olea Europaea) – Offers strong anti-inflammatory and antioxidant effects.

12. Dunaliella Salina Extract – Provides beta-carotene to protect from UV damage.

13. Pomegranate Extract (Punica Granatum) – Regenerates skin cells and fights free radicals.

14. Tremella Fuciformis (Snow Mushroom) – Deeply hydrates and enhances skin barrier function.

15. Tocopheryl Acetate (Vitamin E) – Acts as an antioxidant that protects against free radical damage

Best Vitamin C Serum for Beginners

If you want to try an inexpensive serum first when beginning Vitamin C serums, there are a few good ones. If you like them, you can upgrade to a more expensive better Vitamin C.

I suggest these Top 5 Vitamin C Serums for beginners:

Cera Ve Skin Renewing Vitamin C Serum

Derma Made Antioxidant C Serum +

La Roche Posay Vitamin C Serum

Replenix Age Restore Vitamin C Brightening Serum

Skinceuticals Serum 10 AOX+

Take our quiz to find out if these are right for you.

Take the Quiz

Factors To Consider when Shopping for Vitamin C Serums

Many Vitamin C products, especially the cheap ones, are pretty worthless. But how do you know if a Vitamin C product is good?

There are 5 things that dermatologists like me look at when deciding if a Vitamin C Serum is good:

1. Type of Vitamin C

2. Formulation: serum, lotion, or cream

3. Manufacturing process

4. Packaging

5. pH

These will be discussed below where I discuss different types of Vitamin C in skincare. Vitamin C serum effectiveness also depends on:

Other ingredients in the Vitamin C

Other products used together with the Vitamin C

Which step in the routine the VItamin C is used

Types of Vitamin C In Prodcuts

L-Ascorbic Acid

L-ascorbic acid is the form of Vitamin C that has the most data that shows that it increases collagen production, so this is the type used in the bestselling Vitamin C serums. L-ascorbic acid is hydrophilic so it works best in liquids and serums with water and not a lot of oil.

L-ascorbic acid has a few issues to considering when choosing a good medical grade Vitamin C product. It is very unstable so if it is manufactured and packaged with exposure to air or light, it has no activity. This is why you should never buy a Vitamin C cream in a jar. You need an airless pump or an amber bottle with a small neck.

L-ascorbic acid absorbs best at a low pH, so the best Vitamin C serums may sting when you apply them and can irritate sensitive skin types.

L-ascorbic acid is not right for some sensitive skin types and skin types with hyperpigmentation. There are other forms of ascorbic acid that can be used.

Ascorbic Acid Polypeptide

Ascorbic Acid Polypeptide (15) is a newer form of Vitamin C that’s bound to polypeptides. It is claimed that it allows for improved delivery and stability. This form is designed to convert to L-ascorbic acid once absorbed into the skin, offering the benefits of L-ascorbic acid without its instability and irritation. There is not a lot of evidence-based research available to fully confirm its efficacy and benefits compared to more traditional forms of Vitamin C.

Ascorbyl Palmitate

Ascorbyl palmitate is a fat-soluble form of Vitamin C. It’s an ester formed from ascorbic acid and palmitic acid, leading to a compound that integrates well into lipid-rich skin layers.

The downside of ascorbyl palmitate is that it is less potent compared to L-ascorbic acid. Its antioxidant capacity is considered weaker, and it may not provide as dramatic results in terms of collagen production and photoprotection. There’s also some debate about its stability and efficacy once applied to the skin, with studies suggesting it may not be as effective in penetrating the skin or providing the desired antioxidant benefits. More data is needed to know if this form of Vitamin C is effective.

As far as safety, one study(17) investigated the effects of Ascorbyl Palmitate (AA6P) on skin exposed to UVB radiation. It found that while AA6P can reduce cellular levels of reactive oxygen species (ROS) and had antioxidant properties, it paradoxically promotes lipid peroxidation (LPO), JNK activation, and cytotoxicity when exposed to UVB. This suggests that, despite its antioxidant capabilities, AA6P may exacerbate skin damage under UVB exposure, indicating a complex interaction between its antioxidant effects and its potential to generate harmful oxidized lipid metabolites.

Ascorbyl Tetraisopalmitate

Ascorbyl Tetraisopalmitate, an oil-soluble Vitamin C derivative, offers enhanced stability and deeper skin penetration, making it ideal for sensitive skin. It effectively combats free radicals, supports collagen production, and reduces hyperpigmentation. However, it’s costlier than other forms and might be less potent in stimulating collagen compared to L-ascorbic acid, but its gentleness and efficacy in brightening and anti-aging care make it a valuable skincare choice.

Magnesium Ascorbyl Phosphate (MAP)

Magnesium Ascorbyl Phosphate is another water-soluble form of Vitamin C, appreciated for its stability and effectiveness in lower concentrations. MAP is particularly known for its ability to hydrate the skin, brighten the complexion, and even out skin tone. It’s a great option for those looking to reduce the appearance of dark spots and fine lines without the risk of irritation commonly associated with more potent forms of Vitamin C.

MAP is gentler and less likely to cause irritation than L-ascorbic acid, making it suitable for sensitive skin types. However, it might not provide as dramatic results in collagen production as L-ascorbic acid.

Sodium Ascorbyl Phosphate (SAP)

Sodium Ascorbyl Phosphate is a water-soluble form of Vitamin C that’s known for its stability and gentle nature. It’s an excellent choice for those with acne-prone and sensitive skin types because it’s less irritating than L-ascorbic acid. SAP has been shown to have antimicrobial properties, making it effective in combating acne-causing bacteria. It also offers antioxidant protection, helping to mitigate the effects of free radicals and potentially reduce the signs of aging.

However, while SAP is effective for acne and gentle on the skin, it may not be as potent in stimulating collagen production or in brightening as L-ascorbic acid. Its benefits are more towards protecting against oxidative stress and less about reversing the signs of aging.

Tetrahexyldecyl Ascorbate

Tetrahexyldecyl ascorbate is a form of Vitamin C that’s fat-soluble, which allows it to penetrate the skin’s lipid layers more effectively than some other forms. This characteristic makes it a great option for delivering antioxidant benefits deeper into the skin, potentially improving hydration, elasticity, and the appearance of fine lines. It’s also less irritating than L-ascorbic acid, making it suitable for those with sensitive skin.

However, while tetrahexyldecyl ascorbate is more stable and less irritating, it’s important to note that the research supporting its effectiveness in stimulating collagen production and brightening skin is less extensive than that of L-ascorbic acid. Additionally, products containing this form of Vitamin C can be more expensive due to the cost of formulation and stability.

Tetrahexyldecyl ascorbate is often used to lighten dark spots but its skin lightening activity has to do with its antioxidant properties.

Are Skinceuticals Serums Worth The Money?

Vitamin C serums by SkinCeuticals are worth the money- but- you may not even need a Vitamin C serum. Vitamin C increases collagen levels and has been shown to brighten skin and reduce fine lines and wrinkles. But is it right for you? There are better ways to lighten dark spots and erase wrinkles. Are there better options to spend your money on? We can help you find affordable Vitamin C that is right for you. And you can use your accumulated points in our loyalty program to lower the cost. All you need to do is shop for Vitamin C serums with your Baumann Skin Type.

Make sure Vitamin C is the best product for your skin type before spending the money.

DQH Can I use salicylic acid first and then vitamin C? It’s easy to create a skincare routine, but knowing how to use it is another thing entirely. In most cases, if you’re not getting the desired skin results, it could be due to the layering of conflicting ingredients. So, is it possible that salicylic acid and vitamin C are such ingredients? Or are these active ingredients the duo that’s been missing from your skincare routine? If you want answers, stick around because today we are going to explain the benefits of salicylic acid and vitamin C and how they can be used in your daily life. What are the benefits of salicylic acid for skin? Salicylic acid is one of the most commonly used beta hydroxy acids and is favored by many people with oily, acne-prone skin. This acid is derived from willow bark, and unlike its water-soluble relatives (called alpha-hydroxy acids), salicylic acid is oil-soluble, which means it can penetrate deeper into the lower layers of the skin. Once it reaches the lower layers, it can help unclog pores of excess sebum, dirt, bacteria, debris, and impurities. This results in clearer skin tones and greater definition. Not only does salicylic acid benefit the underlying layers, but the outer surface of the skin benefits as well. When applied to the skin, salicylic acid removes the buildup of dead skin cells. This is accomplished by breaking the bonds that hold dead cells to the surface. Over time, this can cause the complexion to look dull and prone to acne, blackheads, and other blemishes. If you’d like to learn more about salicylic acid and how it can improve your skin, check out this dedicated blog post from a beauty insider. What are the benefits of vitamin C for skin? Vitamin C is considered one of the most powerful antioxidants, which means it is very effective at fighting free radicals and preventing them from causing further skin damage. Examples of free radicals include pollution, central heating, UV rays and harsh climate. They attack proteins, fats and cell membranes as soon as they come into contact with the skin, causing signs of premature aging such as fine lines and wrinkles as well as hyperpigmentation, flaky patches of skin and loss of elasticity. Many people usually prefer to use vitamin C in their morning routine as this ingredient gives the complexion a radiant glow. You’ll also find that vitamin C can target areas of hyperpigmentation, plumping the skin and reducing the appearance of fine lines and wrinkles. The thing about vitamin C is that there are a lot of outdated studies going back to the 1950s that describe vitamin C as an unstable skin component. Thanks to improvements in modern technology, this is no longer the case as all products now contain a stable form of vitamin C. Visit The Beauty Insider to learn more about vitamin C. So please check out our blog post. Can I use salicylic acid first and then vitamin C? Yes, you absolutely can. In fact, it’s thought that using salicylic acid before using vitamin C ensures it penetrates faster and works faster. This is an efficient way to utilize two power sources, and the reason has to do with pH. For example, the skin’s natural pH is about 4.7, making it slightly acidic. Salicylic acid and vitamin C are also both acidic, and you’ll find that vitamin C is absorbed quickly into the skin. Therefore, using salicylic acid beforehand can increase the acidity of the skin and allow vitamin C to penetrate into the skin faster. While this is considered an effective way to combine two powerful ingredients, you need to be aware of your skin type and how it reacts to certain active ingredients. Even people with perfect, normal skin can experience skin sensitivity and irritation. Therefore, always consult a doctor or dermatologist before using any new products on your skin. It’s also important to follow skin application rules. In this case, you need to use the product correctly to ensure you get the best results for your skin. If you’re not sure what I mean, the basic rule for skin is to start with the thinnest consistency and work your way up to the thickest consistency. This prevents a barrier from forming on the surface, preventing other active ingredients from penetrating the skin. Can I use salicylic acid at night and vitamin C in the morning? Yes, absolutely, this is considered the most effective way to get returns without any adverse side effects. This is because there is enough time between applications to ensure that the skin’s pH levels return to balance. You’ll also find that Vitamin C is rich in antioxidants and is perfect for use in the morning to ensure your skin is protected and looking its healthiest. Due to the small size of salicylic acid molecules, it is an acid that is able to reach the deepest parts of the skin. While this is effective at keeping skin clear, it also increases the risk of irritation and photosensitivity. Therefore, many people prefer to use powerful BHAs in their evening routine without exposure to UV rays, pollution, or harsh weather. Warning: If you avoid using sunscreen every day, none of these ingredients will do what your skin needs. The combination of chemical peels and powerful ingredients increases the risk of further damage to the skin’s surface. Use SPF 50 every day to keep your skin protected and your lipid barrier healthy, even on cloudy days, keeping your skin in top condition.
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