Digital Clinic for Skin & Hair Care That Works!

Menu
  • Home
  • Skin Care
  • Beauty
  • Health
Home
Skin Care
The Role of TGF-β in Effective Anti-Aging Skin Care
Skin Care

The Role of TGF-β in Effective Anti-Aging Skin Care

26 May 2025


Transforming Growth Factor Beta (TGF-β) in Skin Serums

Transforming growth factor beta, commonly known as TGF-β or TGF-β, is an important growth factor in anti-aging serums.

TGF-β in the skin promotes collagen production and is therefore added to many anti-aging serums. However, growth factors in skin care products may be unstable and unable to penetrate the skin.

(1) Is TGF-β serum worth buying? Maybe, maybe not.

There are many anti-aging skin care serums on the market that contain anti-aging ingredients. How do you know which one is the best?

The only scientifically sound way to find the growth factor or anti-aging serum that is best for you is to study your Bowman skin type.

What is TGF-β?

TGF-β is the most important growth factor that regulates the production of extracellular matrix (ECM) proteins (such as collagen and elastin) and glycosaminoglycans (such as hyaluronic acid and heparin sulfate) in the skin.

There are different types of TGF-beta.

TGF-β1 is found in skin care products for skin regeneration, anti-aging treatments, and wound healing. (2)

TGF-β in the Skin

Transforming growth factor beta (TGF-β) is a multifunctional cytokine in the transforming growth factor family.

These proteins play a vital role in regulating various cellular processes including cell proliferation, differentiation, migration, and apoptosis.

In mammals, the TGF-β family consists of several isoforms such as TGF-β1, TGF-β2, and TGF-β3. These are synthesized as precursor proteins and then activated through a complex maturation process.

TGF-β is a potent regulator of many aspects of immune function, wound healing, and tissue regeneration, playing a key role in the development of various tissues and homeostasis.

Effects of Natural TGF-β on Skin

In terms of skin health, TGF-beta plays a vital role in maintaining skin integrity and healing.

It promotes the synthesis of extracellular matrix components such as collagen, elastin, and fibronectin, which are essential for the firmness and elasticity of the skin.

During wound healing, TGF-β is essential for regulating inflammation and recruiting cells to the site of injury, where it supports tissue repair and scar formation.

In addition, it helps regulate the balance of skin cell proliferation and differentiation, thereby maintaining the normal structure and function of the skin.

Dysregulated TGF-β signaling has been linked to a variety of skin disorders, including scarring, fibrosis, and certain inflammatory diseases.

How TGF-β Promotes Skin Collagen Production

Transforming growth factor beta (TGF-β) is a superstar in skin collagen production.

This powerful protein regulates cell growth, proliferation, and differentiation, making it an important player in wound healing and skin regeneration.

When TGF-β binds to receptors on dermal fibroblasts, it triggers a signaling cascade that ultimately stimulates collagen synthesis.

Studies have shown that TGF-β stimulates fibroblasts to produce more type I and type III collagen, the two main structural collagens that make up more than 90% of the dermal matrix.

TGF-beta also inhibits collagen degradation by blocking matrix metalloproteinases.

Additionally, TGF-beta attracts immune cells (i.e. macrophages) to the wound site, where they release more TGF-beta, further boosting collagen formation.

This cytokine can even stimulate fibroblasts to transform into active myofibroblasts, which synthesize abundant collagen as part of the skin repair process.

TGF-beta – Benefits for Skin

TGF-beta has many benefits for the skin, as it activates processes in the skin that make it stronger and younger. It influences many of the processes associated with skin aging.

Therefore, a good TGF-beta product can improve fine lines and skin texture.

This anti-aging growth factor:

 

Stimulates dermal collagen remodeling, increasing collagen production (1),

Increases hyaluronic acid production (4) and

Decreases matrix metalloproteinases (5), enzymes that break down these important skin components.

How does TGF-beta work?

When the TGF-beta receptor is activated, the TGF-beta/Smad signaling pathway is activated. This important signaling pathway helps the skin rejuvenate.

Do TGF-β serums really work?

TGF-β is applied topically to the skin in the form of serums, creams, or lotions and is designed to be absorbed by the skin.

The TGF-β molecule itself is relatively large and has difficulty penetrating the outermost layer of the skin (the stratum corneum).

To increase its penetration, it is often encapsulated in liposomes or other carrier systems, allowing it to reach deeper layers of the skin and work.

The effectiveness of topical TGF-β skin products may vary depending on the formulation and individual skin type.

Research has not been completed on the effectiveness of topical TGF-β, but some studies suggest that it may have positive effects on the appearance of the skin.

These include reducing wrinkles and improving skin texture and tone, presumably by stimulating collagen production and other skin renewal processes. However, not all formulations are effective.

Skin Care Products with TGF-β

The best brand for TGF-β in skin care is Plated SkinScience. Their revolutionary use of cutting-edge anti-aging technology makes them one of the best brands on the market today!

These are my favorite Plated SkinScience products:

How does TGF-β relate to skin aging?

UV radiation inhibits the TGF-β/Smad signaling pathway, a process known as extrinsic skin aging.

Blocking the TGF-β/Smad signaling pathway can lead to photoaging, skin wrinkling, and the development of skin cancer. (6)

How can I increase levels of TGF-β in my skin?

In addition to using TGF-β in skin serums, there are other ways to stimulate fibroblasts to release more TGF-β.

17β-estradiol increases TGF-β production (7).

Topical application of retinoids increases the activity of the TGF-β/Smad signaling pathway. (8).

Fibroblasts exposed to hypoxia produce more TGF-β. (9).

This is another reason why I prefer retinoids to treat skin wrinkles.

Is TGF-β safe for skin application?

TGF-β appears to be safe when applied to the skin. Indeed, a reduction in TGF-β may make the skin more susceptible to cancer, but more data are needed. (10,11)

DQH Knowledge drop: In your 20s, your skin cell turnover decreases. (Cell turnover is a key component in keeping your skin youthful.) You know what else slows down? Your collagen production. Starting in your 20s, collagen decreases by about 1 percent per year. Should you want to prevent fine lines and wrinkles, start by eliminating behaviors that contribute to premature aging. “If it’s bad for you, it’s bad for your skin,” says dermatologist Michel Somenek. “Cigarette smoking reduces blood flow to the skin and causes premature wrinkling and a dull skin texture. Making the repeated pursed motion to inhale can also cause smoker’s lines. Alcohol and recreational drugs are toxins for the skin that damage its cellular structure and DNA,” Somenek tells us. “The faster you eliminate vices while you are young, the better chance your skin and body have to recuperate.” Also, adopting an anti-aging routine in your 20s is key. After all, the best offense is a good defense. We spoke to Somenek and experts Joshua Ross and Audrey Kunin to find out more. Keep reading for the best anti-aging products for your 20s, according to skincare professionals. Sunscreen “We all know that the sun is the number one cause of skin aging and starting the prevention in your 20s is very important,” Ross says. “The majority of your sun damage won’t start to appear until you’re in your 30s, so don’t wait until you see it surface or you’ll be behind the curve. Stay ahead of it with a good-quality zinc-based sunscreen worn daily.” Farmacy Green Defense Daily Mineral Sunscreen An invisible sunscreen with SPF 30, plus botanical extracts meant to protect skin with tons of antioxidants. Bonus: It’s clean and fine to use under makeup. Bareminerals Complexion Rescue™ Tinted Moisturizer Broad Spectrum SPF 30 Although we recommend you use your SPF and moisturizer separately, we also understand moments when you don’t have time or energy for that extra step. For those times, this bareMinerals moisturizer is a great thing to have on hand. Vitamin C Serum “A great introduction to anti-aging is to start with a vitamin C serum in your morning skincare routine,” Ross says. “It’s a powerful antioxidant that will neutralize free radicals and brighten the skin.” He adds that it’s a great way to counteract the effects of the sun’s harmful rays, which, as previously mentioned, are among the biggest causes of premature aging. Drunk Elephant C-Firma™ Vitamin C Day Serum The Drunk Elephant C-Firma is a lightweight serum that promises to give skin a glow by combining the brightening powers of vitamin C with ferulic acid, l-ascorbic acid, and vitamin E. The included sodium hyaluronate is meant to replace hydration loss, so you shouldn’t have to deal with any irritation. Sunday Riley C.E.O. Rapid Flash Brightening Serum This potent serum is jam-packed with vitamin C (15 percent, to be exact), which means it’s a potential superstar at both brightening skin and dousing it in antioxidants. Peptides Using peptides on your skin has many benefits, says Somenek. “The skin barrier is what defends the body against pollution, UV rays, bacteria, and toxins. It can be damaged by several everyday factors. Using topical peptides aids in building a stronger barrier,” he says. “Peptides comprise elastic fibers, which are a type of protein. These fibers help to make skin appear taut and firm. Peptides can also help repair damaged skin, relieve inflammation, and even out skin tone. Some peptides can kill acne-causing bacteria that is common in 20-somethings.” Kunin agrees, saying, “Peptides are an excellent entry point for supporting collagen.” She recommends looking for face and eye treatments that contain these collagen-boosting powerhouses. Charlotte Tilbury Magic Eye Rescue Cream This Charlotte Tilbury super-emollient eye cream has a base of coconut oil and shea butter (read: it’s incredibly hydrating). Botanicals plus peptides are meant to help reduce dark circles and boost collagen, respectively. This creamy moisturizer serves up potent collagen-boosting peptides and pycnogenol, and antioxidant-rich vitamin C. “Instead of sitting on top of the skin, peptides penetrate the outer layer so they go deep. The ‘signals’ they send tell the cells to produce elastin and collagen, which are needed for youthful-looking skin,” explains Somenek. At-Home Peel Pads Remember that skin cell turnover fiasco we talked about earlier? One way to help support it is by exfoliating. “Exfoliation is important to help keep skin fresh and luminous,” Kunin says. She recommends using at-home peel pads as an easy and effective way to exfoliate. “The goal in your 20s is to fight the slowing pace of cell turnover. It is wise to use products that gently exfoliate, yet still remove oil and other impurities. Products that have Alpha Hydroxy Acids (AHA) or Beta Hydroxy Acids (BHA) are a good choice.” According to Somenek, you should only exfoliate two to three times a week. “People of all ages are guilty of over-exfoliating and that can be too much of a good thing,” he says. Dermadoctor Kakadu C Intensive Vitamin C Peel Pad A few swipes of this Derma Doctor powerful peel pad promise to leave your skin glowing and smooth, thanks to the seven (yes, seven) types of chemical exfoliants, including AHA and BHA. It also contains vitamin C via Kakadu plum extract for added brightening and antioxidant protection. KEY INGREDIENTS Kakadu plum extract is sourced from the Kakadu plum, a fruit grown in northern Australia. It contains vitamin C, which restores the skin’s natural barrier, increases collagen production, and soothes irritation. Dr. Dennis Gross Skincare Alpha Beta® Universal Daily Peel Pads These are the gold standard of peel pads, with a cult following and over 900 five-star reviews on Sephora. They’re easy to use and contain a blend of anti-aging exfoliating acids. Emollient Night Cream “In your 20s, you need to start upping the hydration in your skincare routine. You may have been cautious of over-moisturizing because of acne in your teens, but as you enter your 20s, your skin transitions and becomes drier,” Ross says. “I recommend an emollient night cream added into your evening skincare regimen.” “Twenty-somethings need to make sure that they are not using creams that will clog their pores and cause excess oil production,” says Somenek. Opt for non-comedogenic products. Cerave Skin Renewing Night Cream One great choice is the CeraVe Skin Renewing Night Cream, which is a non-comedogenic night cream that leaves skin soft and glowy. It combines the moisturizing powers of ceramides and hyaluronic acid. RoC Retinol Correxion Max Hydration Creme “The best night cream ingredients contain retinol, benzoyl peroxide, and/or salicylic acid or hyaluronic acid. The goal is to moisturize, yet remove excess oil,” says Somenek. This Roc Retinol Correxion cream fits the bill as it contains both hyaluronic acid and retinol so it promises to moisturize while also being non-comedogenic.
Share
Tweet
Email
Prev Article
Next Article

Related Articles

Glow Naturally: The Skincare Power of Mulberry Extract

Glow Naturally: The Skincare Power of Mulberry Extract

Skincare 101: The Right Way to Wash Your Face for Healthy, Glowing Skin

Skincare 101: The Right Way to Wash Your Face for Healthy, Glowing Skin

Recent Posts

  • How to Use Vitamin E for Healthy, Glowing Skin
    How to Use Vitamin E for Healthy, …
    28 May 2025 0
  • How Vitamin C Boosts Skin Health: Uses and Precautions
    How Vitamin C Boosts Skin Health: Uses …
    28 May 2025 0
  • Vicks VapoRub: Truths and Myths About Its Skin Care Uses
    Vicks VapoRub: Truths and Myths About Its …
    28 May 2025 0
  • Vibrio Alginolyticus Ferment Filtrate: Powerful Hydration and Skin Renewal
    Vibrio Alginolyticus Ferment Filtrate: Powerful Hydration and …
    28 May 2025 0
  • Which Moisturizer Wins? Vanicream or CeraVe for Your Skin
    Which Moisturizer Wins? Vanicream or CeraVe for …
    28 May 2025 0

Popular Posts

  • Aloe Vera in Skin Care: Healing Benefits and Safety Tips
    Aloe Vera in Skin Care: Healing Benefits …
    27 May 2025 0
  • The Skincare Power of Mandelic Acid for Clearer Skin
    The Skincare Power of Mandelic Acid for …
    29 April 2025 0
  • Skincare with Marula Oil: Safe, Effective, and Natural
    Skincare with Marula Oil: Safe, Effective, and …
    29 April 2025 0
  • Matrixyl for Skin: Safe, Popular, but Does It Work?
    Matrixyl for Skin: Safe, Popular, but Does …
    29 April 2025 0
  • Azelaic Acid in Skincare: A Gentle Yet Powerful Solution
    Azelaic Acid in Skincare: A Gentle Yet …
    29 April 2025 0

Digital Clinic for Skin & Hair Care That Works!

Copyright © 2025 Digital Clinic for Skin & Hair Care That Works!
Theme by MyThemeShop.com

Ad Blocker Detected

Our website is made possible by displaying online advertisements to our visitors. Please consider supporting us by disabling your ad blocker.

Refresh